| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 31 | 31 | 14 | 10 | 3.49 | .294 | 1.23 | 8.4 | 2.6 | 8.7 | 222.0 | 208 | 93 | 86 | 30 | 65 | 215 | 3 | 0 | 0 | 1 | 23 | 4 | 1 | 3.75 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 31 | 31 | 8 | 12 | 4.29 | .303 | 1.27 | 8.9 | 2.6 | 5.7 | 203.2 | 201 | 103 | 97 | 26 | 58 | 128 | 1 | 0 | 0 | 0 | 17 | 7 | 6 | 4.36 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 31 | 31 | 8 | 16 | 5.02 | .332 | 1.48 | 9.5 | 3.9 | 5.0 | 200.2 | 211 | 123 | 112 | 26 | 86 | 110 | 3 | 0 | 0 | 1 | 14 | 2 | 4 | 4.91 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 30 | 30 | 10 | 13 | 5.56 | .321 | 1.39 | 9.3 | 3.2 | 4.7 | 173.1 | 179 | 110 | 107 | 23 | 62 | 90 | 1 | 0 | 0 | 0 | 13 | 5 | 2 | 4.85 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 56 | 0 | 4 | 9 | 4.82 | .317 | 1.36 | 9.9 | 2.4 | 8.5 | 52.1 | 57 | 28 | 28 | 7 | 14 | 49 | 0 | 28 | 7 | 0 | 0 | 2 | 1 | 3.79 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 64 | 0 | 2 | 3 | 3.80 | .295 | 1.22 | 7.3 | 3.8 | 9.4 | 68.2 | 55 | 29 | 29 | 10 | 29 | 71 | 0 | 1 | 7 | 0 | 0 | 2 | 0 | 4.19 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 52 | 0 | 2 | 4 | 2.75 | .310 | 1.31 | 6.9 | 5.1 | 9.3 | 55.2 | 42 | 17 | 17 | 2 | 31 | 57 | 0 | 3 | 0 | 0 | 0 | 2 | 1 | 3.20 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 41 | 0 | 2 | 1 | 3.26 | .314 | 1.32 | 5.7 | 6.4 | 10.2 | 38.2 | 24 | 19 | 14 | 7 | 27 | 43 | 0 | 1 | 0 | 0 | 0 | 2 | 6 | 5.42 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 27 | 0 | 0 | 3 | 4.60 | .333 | 1.50 | 9.6 | 4.0 | 11.5 | 29.1 | 31 | 17 | 15 | 3 | 13 | 37 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.14 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 21 | 1 | 5 | 2 | 3.33 | .270 | 1.07 | 6.6 | 3.1 | 4.8 | 78.1 | 57 | 32 | 29 | 7 | 27 | 42 | 1 | 0 | 0 | 1 | 1 | 3 | 1 | 4.24 |