| SP | Arrieta, J.Arrieta, Jake $ >> | 25 | 2015 | R | 95 | 35 | 35 | 16 | 11 | 4.11 | .299 | 1.26 | 8.0 | 3.4 | 9.1 | 247.2 | 219 | 121 | 113 | 40 | 93 | 250 | 4 | 0 | 0 | 1 | 20 | 5 | 10 | 4.27 |
| SP | Hunter, C.Hunter, Catfish >> | 25 | 1972 | R | 83 | 33 | 33 | 16 | 11 | 4.65 | .322 | 1.40 | 8.8 | 3.8 | 7.0 | 226.1 | 221 | 118 | 117 | 28 | 95 | 175 | 2 | 0 | 0 | 1 | 17 | 6 | 4 | 4.40 |
| SP | Darvish, Y.Darvish, Yu >> | 25 | 2013 | R | 58 | 33 | 33 | 13 | 7 | 4.80 | .343 | 1.53 | 8.7 | 5.1 | 9.9 | 193.0 | 186 | 110 | 103 | 18 | 110 | 213 | 0 | 0 | 0 | 0 | 15 | 6 | 6 | 3.81 |
| RP | Soriano, R.Soriano, Rafael >> | 25 | 2003 | R | 83 | 93 | 0 | 8 | 2 | 3.95 | .311 | 1.34 | 8.8 | 3.2 | 11.0 | 118.1 | 116 | 53 | 52 | 10 | 42 | 144 | 0 | 1 | 4 | 0 | 0 | 2 | 0 | 2.78 |
| RP | Gregerson, L.Gregerson, Luke >> | 25 | 2010 | R | 72 | 74 | 0 | 3 | 1 | 4.41 | .319 | 1.37 | 10.3 | 2.0 | 9.0 | 49.0 | 56 | 26 | 24 | 10 | 11 | 49 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.45 |
| CL | Soria, J.Soria, Joakim >> | 25 | 2008 | R | 67 | 60 | 0 | 5 | 8 | 4.06 | .290 | 1.23 | 8.6 | 2.5 | 5.9 | 64.1 | 61 | 30 | 29 | 6 | 18 | 42 | 0 | 15 | 3 | 0 | 0 | 0 | 1 | 3.75 |
| SU | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 53 | 0 | 0 | 2 | 5.51 | .356 | 1.62 | 8.8 | 5.9 | 7.6 | 50.2 | 49 | 32 | 31 | 7 | 33 | 42 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 5.24 |
| RP | Harvey, B.Harvey, Bryan † >> | 25 | 1991 | R | 64 | 58 | 0 | 3 | 7 | 6.71 | .362 | 1.70 | 10.9 | 4.5 | 9.5 | 52.1 | 63 | 42 | 39 | 15 | 26 | 55 | 0 | 25 | 10 | 0 | 0 | 0 | 4 | 6.13 |
| RP | Urbina, U.Urbina, Ugueth >> | 25 | 1998 | R | 59 | 45 | 0 | 2 | 1 | 6.80 | .394 | 1.88 | 8.2 | 9.0 | 9.4 | 43.2 | 39 | 34 | 33 | 7 | 43 | 45 | 0 | 0 | 1 | 0 | 0 | 3 | 2 | 6.23 |
| SP | Weaver, J.Weaver, Jered >> | 25 | 2011 | R | 56 | 3 | 0 | 0 | 2 | 1.50 | .357 | 1.67 | 12.0 | 3.0 | 12.0 | 6.0 | 8 | 7 | 1 | 1 | 2 | 8 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.50 |