| SP | Tiant, L.Tiant, Luis † >> | 28 | 1968 | R | 97 | 36 | 36 | 18 | 11 | 3.12 | .287 | 1.20 | 7.3 | 3.5 | 8.5 | 248.1 | 201 | 97 | 86 | 22 | 96 | 235 | 5 | 0 | 0 | 1 | 26 | 3 | 4 | 3.46 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 34 | 34 | 12 | 13 | 4.44 | .307 | 1.29 | 9.1 | 2.5 | 8.7 | 219.0 | 221 | 108 | 108 | 30 | 62 | 211 | 1 | 0 | 0 | 0 | 19 | 8 | 3 | 3.81 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 64 | 0 | 6 | 9 | 2.11 | .229 | 0.86 | 5.2 | 2.6 | 10.1 | 68.1 | 39 | 16 | 16 | 7 | 20 | 76 | 0 | 36 | 5 | 0 | 0 | 2 | 1 | 3.07 |
| SU | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 66 | 0 | 0 | 0 | 3.25 | .293 | 1.24 | 9.6 | 1.7 | 8.6 | 63.2 | 67 | 25 | 23 | 5 | 12 | 60 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 2.70 |
| RP | Boxberger, B.Boxberger, Brad # >> | 26 | 2014 | R | 83 | 65 | 0 | 3 | 1 | 3.67 | .296 | 1.24 | 7.6 | 3.7 | 9.6 | 56.1 | 47 | 23 | 23 | 5 | 23 | 60 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.30 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 51 | 0 | 6 | 3 | 2.80 | .287 | 1.21 | 7.7 | 3.3 | 6.7 | 54.2 | 46 | 19 | 17 | 5 | 20 | 40 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.83 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 34 | 0 | 3 | 2 | 4.37 | .314 | 1.34 | 9.8 | 2.3 | 6.7 | 35.0 | 38 | 19 | 17 | 6 | 9 | 26 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.60 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 10 | 0 | 0 | 2 | 3.55 | .296 | 1.22 | 7.9 | 3.2 | 9.4 | 25.1 | 22 | 10 | 10 | 4 | 9 | 26 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.20 |