| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 7 | 7 | 4 | 2 | 1.78 | .248 | 0.99 | 7.2 | 1.8 | 8.8 | 50.2 | 40 | 10 | 10 | 1 | 10 | 49 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | 1.90 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 7 | 7 | 3 | 2 | 3.02 | .251 | 1.01 | 7.7 | 1.4 | 8.1 | 50.2 | 43 | 17 | 17 | 4 | 8 | 45 | 1 | 0 | 0 | 0 | 5 | 0 | 2 | 2.72 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 7 | 7 | 1 | 5 | 8.50 | .379 | 1.83 | 11.5 | 5.0 | 10.0 | 36.0 | 46 | 35 | 34 | 8 | 20 | 40 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 5.33 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 26 | 0 | 1 | 1 | 3.14 | .283 | 1.19 | 6.4 | 4.5 | 8.4 | 14.1 | 10 | 6 | 5 | 2 | 7 | 13 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 4.50 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 20 | 0 | 0 | 1 | 4.05 | .259 | 0.98 | 6.9 | 2.1 | 9.7 | 13.1 | 10 | 6 | 6 | 2 | 3 | 14 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 3.77 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 9 | 0 | 0 | 0 | 1.64 | .298 | 1.27 | 4.9 | 6.5 | 8.2 | 11.0 | 6 | 2 | 2 | 0 | 8 | 10 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.36 |