| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 34 | 34 | 11 | 17 | 3.95 | .297 | 1.24 | 9.0 | 2.3 | 9.7 | 223.1 | 222 | 106 | 98 | 23 | 56 | 241 | 1 | 0 | 0 | 1 | 16 | 5 | 0 | 3.00 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 33 | 33 | 9 | 16 | 4.40 | .317 | 1.36 | 9.5 | 2.9 | 9.2 | 220.2 | 231 | 114 | 108 | 19 | 70 | 225 | 3 | 0 | 0 | 2 | 17 | 6 | 5 | 3.11 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 32 | 32 | 10 | 17 | 5.21 | .326 | 1.43 | 9.5 | 3.3 | 8.5 | 216.0 | 229 | 133 | 125 | 24 | 79 | 204 | 5 | 0 | 0 | 2 | 15 | 5 | 4 | 3.72 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 111 | 0 | 3 | 5 | 4.22 | .304 | 1.29 | 7.8 | 3.9 | 7.8 | 70.1 | 61 | 34 | 33 | 7 | 30 | 61 | 0 | 4 | 5 | 0 | 0 | 1 | 0 | 3.89 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 76 | 0 | 2 | 4 | 3.62 | .292 | 1.19 | 8.2 | 2.6 | 9.9 | 59.2 | 54 | 27 | 24 | 11 | 17 | 65 | 0 | 9 | 4 | 0 | 0 | 3 | 0 | 4.24 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 34 | 0 | 2 | 0 | 2.20 | .259 | 1.02 | 4.6 | 4.6 | 10.1 | 41.0 | 21 | 12 | 10 | 3 | 21 | 46 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 3.32 |