| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 25 | 25 | 11 | 11 | 4.07 | .284 | 1.15 | 7.9 | 2.5 | 8.4 | 177.0 | 155 | 86 | 80 | 21 | 49 | 166 | 8 | 0 | 0 | 2 | 16 | 7 | 3 | 3.62 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 24 | 24 | 5 | 12 | 6.09 | .352 | 1.61 | 11.6 | 3.0 | 4.4 | 115.1 | 148 | 78 | 78 | 18 | 38 | 56 | 0 | 0 | 0 | 0 | 4 | 2 | 6 | 5.10 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 50 | 0 | 4 | 5 | 5.05 | .265 | 1.03 | 7.4 | 1.9 | 9.5 | 51.2 | 42 | 29 | 29 | 10 | 11 | 54 | 0 | 18 | 2 | 0 | 0 | 3 | 0 | 4.25 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 60 | 0 | 2 | 0 | 2.55 | .300 | 1.28 | 7.8 | 3.8 | 10.2 | 67.0 | 58 | 20 | 19 | 4 | 28 | 76 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 2.76 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 67 | 0 | 3 | 6 | 5.35 | .335 | 1.49 | 9.6 | 3.9 | 9.9 | 70.2 | 75 | 43 | 42 | 13 | 30 | 77 | 0 | 1 | 4 | 0 | 0 | 2 | 1 | 4.59 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 47 | 0 | 2 | 0 | 6.79 | .347 | 1.59 | 11.2 | 3.3 | 7.6 | 58.1 | 72 | 44 | 44 | 5 | 21 | 49 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.52 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 41 | 0 | 1 | 0 | 4.56 | .263 | 1.05 | 6.0 | 3.5 | 6.4 | 51.1 | 34 | 26 | 26 | 11 | 20 | 36 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.63 |