| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 8 | 8 | 5 | 0 | 2.00 | .264 | 1.07 | 8.5 | 1.2 | 11.3 | 54.0 | 51 | 14 | 12 | 2 | 7 | 68 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 1.35 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 7 | 7 | 3 | 1 | 5.65 | .355 | 1.63 | 11.7 | 2.9 | 7.7 | 43.0 | 56 | 28 | 27 | 2 | 14 | 37 | 0 | 0 | 0 | 0 | 3 | 1 | 2 | 2.93 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 7 | 7 | 3 | 3 | 4.63 | .271 | 1.09 | 8.2 | 1.8 | 5.3 | 46.2 | 42 | 25 | 24 | 8 | 9 | 27 | 1 | 0 | 0 | 0 | 4 | 1 | 0 | 4.74 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 7 | 7 | 3 | 3 | 3.78 | .299 | 1.28 | 9.6 | 2.1 | 4.6 | 47.2 | 50 | 20 | 20 | 11 | 11 | 24 | 3 | 0 | 0 | 0 | 5 | 0 | 0 | 5.72 |
| SP | McDowell, S.McDowell, Sam >> | 26 | 1968 | L | 46 | 7 | 7 | 1 | 3 | 7.17 | .358 | 1.67 | 10.7 | 4.6 | 8.3 | 37.2 | 44 | 30 | 30 | 11 | 19 | 34 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 6.57 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 12 | 0 | 0 | 0 | 4.38 | .383 | 1.86 | 12.0 | 5.3 | 9.8 | 12.1 | 16 | 6 | 6 | 1 | 7 | 13 | 0 | 7 | 3 | 0 | 0 | 0 | 0 | 3.67 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 21 | 0 | 0 | 0 | 3.55 | .333 | 1.50 | 10.5 | 3.8 | 9.8 | 12.2 | 14 | 5 | 5 | 0 | 5 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 2.08 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 17 | 0 | 2 | 2 | 6.23 | .358 | 1.62 | 8.5 | 6.4 | 7.9 | 17.1 | 16 | 12 | 12 | 5 | 12 | 15 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 7.35 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 11 | 0 | 0 | 1 | 2.45 | .254 | 1.02 | 6.4 | 3.2 | 8.4 | 14.2 | 10 | 4 | 4 | 0 | 5 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.21 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 74 | 10 | 0 | 1 | 2 | 6.10 | .279 | 1.16 | 9.0 | 1.8 | 9.0 | 10.1 | 10 | 7 | 7 | 3 | 2 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.50 |
| SP | Newhouser, H.Newhouser, Hal >> | 25 | 1946 | L | 31 | 4 | 0 | 1 | 0 | 5.09 | .391 | 1.92 | 13.2 | 4.8 | 4.2 | 17.2 | 25 | 18 | 10 | 4 | 9 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 6.71 |