| SP | Scherzer, M.Scherzer, Max >> | 34 | 2018 | R | 97 | 38 | 38 | 13 | 17 | 3.98 | .290 | 1.21 | 8.5 | 2.4 | 8.2 | 260.1 | 245 | 120 | 115 | 28 | 69 | 238 | 2 | 0 | 0 | 1 | 21 | 5 | 2 | 3.42 |
| SP | Leonard, D.Leonard, Dutch # $$ >> | 22 | 1914 | L | 94 | 36 | 36 | 15 | 12 | 3.08 | .272 | 1.11 | 7.1 | 2.9 | 5.5 | 245.2 | 193 | 92 | 84 | 29 | 79 | 151 | 2 | 0 | 0 | 2 | 26 | 3 | 4 | 4.31 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 94 | 36 | 36 | 17 | 9 | 3.68 | .263 | 1.06 | 7.3 | 2.2 | 8.7 | 247.0 | 200 | 107 | 101 | 35 | 61 | 238 | 1 | 0 | 0 | 0 | 24 | 3 | 5 | 3.69 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 99 | 76 | 0 | 4 | 2 | 3.33 | .250 | 0.99 | 6.1 | 2.8 | 9.6 | 81.0 | 55 | 30 | 30 | 12 | 25 | 86 | 0 | 30 | 3 | 0 | 0 | 1 | 2 | 3.77 |
| CL | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 93 | 56 | 0 | 3 | 2 | 2.16 | .246 | 0.94 | 6.1 | 2.3 | 8.8 | 50.0 | 34 | 12 | 12 | 3 | 13 | 49 | 0 | 31 | 2 | 0 | 0 | 2 | 0 | 2.72 |
| RP | Clase, E.Clase, Emmanuel >> | 24 | 2022 | R | 91 | 19 | 0 | 2 | 0 | 3.50 | .260 | 1.06 | 8.0 | 1.5 | 6.0 | 18.0 | 16 | 7 | 7 | 2 | 3 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.61 |
| RP | Holton, T.Holton, Tyler >> | 27 | 2023 | L | 76 | 13 | 0 | 1 | 1 | 2.87 | .230 | 0.89 | 6.0 | 2.4 | 5.4 | 15.2 | 10 | 5 | 5 | 3 | 4 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.20 |
| RP | Ottavino, A.Ottavino, Adam >> | 32 | 2018 | R | 74 | 14 | 0 | 0 | 0 | 3.86 | .222 | 0.86 | 2.8 | 5.1 | 10.7 | 16.1 | 5 | 7 | 7 | 0 | 9 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.31 |