| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 16 | 16 | 1 | 1 | 4.19 | .324 | 1.41 | 9.1 | 3.6 | 11.6 | 73.0 | 74 | 35 | 34 | 4 | 29 | 94 | 0 | 0 | 0 | 0 | 0 | 2 | 5 | 2.41 |
| SP | Williams, W.Williams, Woody # >> | 36 | 2002 | R | 78 | 15 | 15 | 6 | 4 | 5.98 | .350 | 1.58 | 11.1 | 3.2 | 6.2 | 87.1 | 107 | 61 | 58 | 16 | 31 | 60 | 1 | 0 | 0 | 0 | 5 | 3 | 1 | 5.18 |
| SP | Alvarez, W.Alvarez, Wilson # >> | 33 | 2003 | L | 73 | 15 | 15 | 2 | 5 | 5.74 | .343 | 1.55 | 11.0 | 3.0 | 6.3 | 69.0 | 84 | 46 | 44 | 12 | 23 | 48 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.91 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 72 | 15 | 15 | 6 | 9 | 5.12 | .337 | 1.50 | 9.6 | 4.0 | 5.6 | 103.2 | 110 | 59 | 59 | 19 | 46 | 64 | 3 | 0 | 0 | 1 | 6 | 2 | 0 | 5.55 |
| RP | Balfour, G.Balfour, Grant $ >> | 31 | 2008 | R | 90 | 36 | 0 | 6 | 1 | 4.12 | .318 | 1.37 | 7.1 | 5.4 | 10.7 | 43.2 | 34 | 21 | 20 | 1 | 26 | 51 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 2.81 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 86 | 48 | 0 | 5 | 1 | 4.86 | .303 | 1.29 | 10.4 | 1.4 | 8.8 | 53.2 | 61 | 29 | 29 | 9 | 8 | 52 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.75 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 34 | 0 | 2 | 1 | 4.39 | .324 | 1.41 | 9.2 | 3.5 | 8.1 | 41.0 | 42 | 22 | 20 | 8 | 16 | 37 | 0 | 4 | 2 | 0 | 0 | 1 | 2 | 4.98 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 64 | 46 | 0 | 4 | 1 | 3.33 | .295 | 1.21 | 8.4 | 2.6 | 7.3 | 48.2 | 45 | 18 | 18 | 7 | 14 | 39 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 4.27 |
| RP | Takatsu, S.Takatsu, Shingo >> | 36 | 2004 | R | 56 | 29 | 0 | 3 | 1 | 4.37 | .335 | 1.46 | 6.9 | 6.2 | 6.9 | 35.0 | 27 | 18 | 17 | 5 | 24 | 27 | 0 | 4 | 2 | 0 | 0 | 2 | 2 | 5.54 |
| SP | Millwood, K.Millwood, Kevin >> | 28 | 2002 | R | 50 | 15 | 0 | 3 | 1 | 5.97 | .323 | 1.40 | 10.0 | 2.9 | 7.7 | 28.2 | 31 | 19 | 19 | 4 | 9 | 24 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 4.21 |