| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 99 | 18 | 18 | 6 | 5 | 4.19 | .312 | 1.35 | 9.3 | 2.9 | 8.9 | 109.2 | 113 | 53 | 51 | 19 | 35 | 108 | 0 | 0 | 0 | 0 | 8 | 1 | 3 | 4.28 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 17 | 9 | 7 | 5 | 4.11 | .307 | 1.29 | 9.5 | 2.2 | 6.9 | 96.1 | 101 | 44 | 44 | 13 | 23 | 74 | 0 | 0 | 0 | 0 | 5 | 4 | 2 | 4.06 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 76 | 16 | 16 | 3 | 5 | 5.47 | .326 | 1.43 | 10.1 | 2.9 | 9.7 | 75.2 | 84 | 46 | 46 | 11 | 24 | 81 | 0 | 0 | 0 | 0 | 6 | 2 | 3 | 3.79 |
| SP | Weaver, J.Weaver, Jered # >> | 24 | 2006 | R | 83 | 17 | 15 | 5 | 6 | 5.45 | .322 | 1.41 | 9.2 | 3.5 | 6.3 | 79.1 | 81 | 52 | 48 | 8 | 31 | 55 | 1 | 0 | 0 | 1 | 8 | 1 | 3 | 4.14 |
| RP | Guardado, E.Guardado, Eddie >> | 34 | 2004 | L | 55 | 9 | 0 | 1 | 1 | 2.79 | .237 | 0.93 | 8.0 | 1.0 | 4.0 | 9.2 | 8 | 5 | 3 | 1 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.89 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 88 | 32 | 0 | 5 | 0 | 2.31 | .286 | 1.20 | 6.9 | 3.9 | 9.0 | 35.0 | 27 | 9 | 9 | 1 | 15 | 35 | 0 | 1 | 2 | 0 | 0 | 0 | 2 | 2.66 |
| SU | Wheeler, D.Wheeler, Dan >> | 32 | 2009 | R | 67 | 35 | 0 | 0 | 0 | 1.70 | .265 | 1.00 | 6.6 | 2.4 | 5.1 | 37.0 | 27 | 10 | 7 | 2 | 10 | 21 | 0 | 4 | 1 | 0 | 0 | 3 | 0 | 3.62 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 85 | 23 | 0 | 2 | 2 | 5.70 | .336 | 1.52 | 9.8 | 4.3 | 10.2 | 23.2 | 25 | 16 | 15 | 2 | 11 | 26 | 0 | 2 | 1 | 0 | 0 | 0 | 4 | 3.30 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 100 | 32 | 0 | 3 | 2 | 3.89 | .278 | 1.13 | 6.4 | 4.0 | 10.3 | 34.2 | 24 | 15 | 15 | 4 | 15 | 39 | 0 | 21 | 6 | 0 | 0 | 1 | 0 | 3.65 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 50 | 7 | 0 | 0 | 0 | 5.06 | .467 | 2.25 | 14.4 | 7.2 | 1.8 | 5.1 | 8 | 5 | 3 | 2 | 4 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 11.40 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 57 | 17 | 9 | 2 | 3 | 7.29 | .383 | 1.83 | 12.7 | 4.0 | 7.0 | 66.2 | 93 | 54 | 54 | 15 | 29 | 51 | 1 | 0 | 0 | 0 | 3 | 2 | 3 | 5.82 |