| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 13 | 13 | 8 | 2 | 2.71 | .243 | 0.94 | 6.9 | 1.6 | 9.5 | 99.2 | 76 | 31 | 30 | 12 | 18 | 105 | 2 | 0 | 0 | 0 | 9 | 2 | 2 | 3.06 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 88 | 12 | 12 | 7 | 5 | 5.65 | .352 | 1.63 | 10.3 | 4.6 | 9.0 | 71.2 | 81 | 46 | 45 | 9 | 36 | 71 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 4.17 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 76 | 12 | 12 | 4 | 2 | 4.18 | .340 | 1.48 | 10.5 | 2.8 | 7.7 | 84.0 | 98 | 44 | 39 | 9 | 26 | 72 | 0 | 0 | 0 | 0 | 6 | 6 | 0 | 3.82 |
| SP | Perez, O.Perez, Oliver >> | 23 | 2004 | L | 75 | 12 | 12 | 6 | 2 | 3.88 | .308 | 1.29 | 7.8 | 3.9 | 10.9 | 67.1 | 58 | 31 | 29 | 4 | 29 | 81 | 1 | 0 | 0 | 0 | 7 | 3 | 1 | 2.79 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 28 | 0 | 2 | 1 | 5.08 | .289 | 1.22 | 8.7 | 2.5 | 8.5 | 33.2 | 32 | 19 | 19 | 5 | 9 | 31 | 0 | 2 | 2 | 0 | 0 | 0 | 5 | 3.91 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 78 | 20 | 0 | 1 | 0 | 3.42 | .313 | 1.37 | 9.3 | 3.1 | 8.0 | 26.1 | 27 | 10 | 10 | 4 | 9 | 23 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 4.27 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 30 | 2002 | R | 54 | 14 | 0 | 1 | 0 | 1.08 | .231 | 0.84 | 6.2 | 1.7 | 10.1 | 16.2 | 11 | 2 | 2 | 0 | 3 | 18 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1.50 |