| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 17 | 17 | 6 | 9 | 4.42 | .299 | 1.26 | 9.1 | 2.3 | 9.1 | 118.0 | 119 | 59 | 58 | 16 | 30 | 119 | 2 | 0 | 0 | 2 | 8 | 2 | 1 | 3.56 |
| SP | Johnson, J.Johnson, Josh # >> | 25 | 2009 | R | 46 | 15 | 15 | 5 | 4 | 4.97 | .321 | 1.40 | 9.6 | 3.1 | 8.9 | 88.2 | 94 | 50 | 49 | 14 | 30 | 87 | 0 | 0 | 0 | 0 | 8 | 2 | 5 | 4.18 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 44 | 0 | 2 | 1 | 3.30 | .277 | 1.13 | 7.5 | 2.7 | 7.8 | 60.0 | 50 | 23 | 22 | 10 | 18 | 52 | 0 | 4 | 5 | 0 | 0 | 1 | 2 | 4.38 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 68 | 36 | 0 | 2 | 4 | 4.20 | .289 | 1.20 | 8.2 | 2.6 | 9.2 | 45.0 | 41 | 23 | 21 | 12 | 13 | 46 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 5.36 |
| RP | Kuo, H.Kuo, Hong-Chih † >> | 27 | 2008 | L | 46 | 31 | 0 | 3 | 1 | 3.47 | .278 | 1.11 | 8.1 | 2.0 | 10.1 | 49.1 | 44 | 20 | 19 | 8 | 11 | 55 | 0 | 6 | 0 | 0 | 0 | 2 | 0 | 3.67 |
| RP | Howell, J.Howell, J.P. >> | 25 | 2008 | L | 33 | 23 | 0 | 3 | 1 | 3.18 | .234 | 0.92 | 6.1 | 2.3 | 12.2 | 28.1 | 19 | 10 | 10 | 3 | 7 | 38 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 2.43 |
| RP | Farnsworth, K.Farnsworth, Kyle >> | 25 | 2001 | R | 22 | 19 | 0 | 1 | 1 | 4.30 | .317 | 1.39 | 8.2 | 4.3 | 7.8 | 23.0 | 21 | 12 | 11 | 2 | 11 | 20 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.83 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 33 | 6 | 1 | 1 | 0 | 2.37 | .260 | 1.05 | 6.6 | 2.8 | 8.5 | 19.0 | 14 | 5 | 5 | 2 | 6 | 18 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 3.42 |