| SP | Johnson, R.Johnson, Randy † >> | 38 | 2001 | L | 97 | 19 | 19 | 10 | 5 | 3.91 | .286 | 1.16 | 7.3 | 3.1 | 10.6 | 129.0 | 105 | 56 | 56 | 12 | 44 | 152 | 4 | 0 | 0 | 1 | 11 | 6 | 1 | 3.02 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 86 | 18 | 18 | 5 | 6 | 5.74 | .346 | 1.55 | 11.3 | 2.7 | 7.0 | 109.2 | 137 | 71 | 70 | 18 | 33 | 85 | 2 | 0 | 0 | 0 | 7 | 4 | 1 | 4.61 |
| SP | Perez, O.Perez, Odalis † # >> | 25 | 2002 | L | 81 | 18 | 18 | 11 | 3 | 3.95 | .273 | 1.10 | 8.3 | 1.7 | 6.6 | 125.1 | 115 | 61 | 55 | 17 | 23 | 92 | 2 | 0 | 0 | 1 | 11 | 3 | 4 | 3.92 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 96 | 42 | 0 | 5 | 1 | 1.97 | .199 | 0.74 | 4.8 | 2.0 | 9.8 | 45.2 | 24 | 10 | 10 | 1 | 10 | 49 | 0 | 26 | 1 | 0 | 0 | 0 | 0 | 1.78 |
| SU | Percival, T.Percival, Troy >> | 38 | 2007 | R | 84 | 46 | 0 | 2 | 3 | 4.15 | .320 | 1.38 | 9.9 | 2.5 | 6.5 | 39.0 | 43 | 22 | 18 | 5 | 11 | 28 | 0 | 2 | 5 | 0 | 0 | 1 | 4 | 4.15 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 45 | 0 | 0 | 1 | 5.09 | .333 | 1.47 | 10.5 | 2.8 | 11.3 | 35.1 | 41 | 20 | 20 | 3 | 11 | 44 | 0 | 2 | 2 | 0 | 0 | 1 | 3 | 2.63 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 53 | 19 | 0 | 1 | 1 | 5.65 | .377 | 1.74 | 9.6 | 6.4 | 10.9 | 14.1 | 15 | 9 | 9 | 2 | 10 | 17 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.79 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 55 | 15 | 0 | 3 | 0 | 4.18 | .297 | 1.23 | 9.2 | 1.9 | 7.5 | 47.1 | 48 | 24 | 22 | 6 | 10 | 39 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.77 |