| SP | Martinez, P.Martinez, Pedro # >> | 29 | 2000 | R | 100 | 13 | 13 | 6 | 3 | 3.13 | .256 | 0.99 | 7.2 | 1.8 | 9.7 | 103.2 | 82 | 37 | 36 | 14 | 21 | 111 | 3 | 0 | 0 | 1 | 9 | 4 | 1 | 3.34 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 87 | 13 | 13 | 5 | 4 | 6.87 | .339 | 1.51 | 10.9 | 2.7 | 7.2 | 76.0 | 92 | 58 | 58 | 19 | 23 | 61 | 1 | 0 | 0 | 0 | 3 | 2 | 0 | 5.63 |
| SP | Carpenter, C.Carpenter, Chris >> | 34 | 2009 | R | 79 | 12 | 12 | 6 | 2 | 4.21 | .314 | 1.34 | 8.5 | 3.7 | 7.1 | 66.1 | 62 | 33 | 31 | 8 | 27 | 52 | 0 | 0 | 0 | 0 | 5 | 2 | 1 | 4.32 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 12 | 12 | 4 | 6 | 6.92 | .356 | 1.64 | 11.6 | 3.3 | 5.3 | 66.1 | 85 | 54 | 51 | 12 | 24 | 39 | 2 | 0 | 0 | 0 | 3 | 1 | 1 | 5.32 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 57 | 12 | 12 | 5 | 5 | 5.24 | .340 | 1.49 | 11.4 | 2.1 | 6.7 | 79.0 | 100 | 48 | 46 | 14 | 18 | 59 | 1 | 0 | 0 | 0 | 5 | 4 | 1 | 4.65 |
| SU | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 86 | 26 | 0 | 1 | 2 | 4.28 | .293 | 1.24 | 10.3 | 1.0 | 9.3 | 27.1 | 31 | 13 | 13 | 5 | 3 | 28 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 3.67 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 88 | 28 | 0 | 1 | 1 | 3.00 | .325 | 1.44 | 9.7 | 3.3 | 9.3 | 27.0 | 29 | 12 | 9 | 1 | 10 | 28 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2.52 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 25 | 0 | 2 | 0 | 3.68 | .267 | 1.09 | 8.2 | 1.6 | 11.5 | 22.0 | 20 | 10 | 9 | 3 | 4 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.77 |
| RP | Sasaki, K.Sasaki, Kazuhiro >> | 33 | 2001 | R | 63 | 19 | 0 | 1 | 1 | 2.36 | .266 | 1.05 | 7.3 | 2.4 | 6.6 | 26.2 | 21 | 7 | 7 | 2 | 7 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.46 |