| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 33 | 33 | 18 | 11 | 3.66 | .315 | 1.34 | 9.0 | 3.1 | 8.7 | 233.1 | 233 | 111 | 95 | 33 | 80 | 226 | 5 | 0 | 0 | 1 | 22 | 9 | 3 | 4.05 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 32 | 32 | 11 | 11 | 4.43 | .311 | 1.32 | 8.7 | 3.2 | 9.4 | 203.0 | 196 | 103 | 100 | 31 | 72 | 213 | 2 | 0 | 0 | 1 | 16 | 7 | 0 | 4.05 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 32 | 32 | 5 | 8 | 5.04 | .339 | 1.48 | 10.3 | 3.0 | 6.9 | 139.1 | 159 | 82 | 78 | 22 | 47 | 107 | 0 | 0 | 0 | 0 | 2 | 8 | 1 | 4.71 |
| SP | Prior, M.Prior, Mark # >> | 23 | 2003 | R | 69 | 32 | 32 | 10 | 10 | 6.46 | .350 | 1.59 | 10.5 | 3.8 | 9.8 | 192.1 | 225 | 148 | 138 | 43 | 80 | 210 | 2 | 0 | 0 | 0 | 10 | 6 | 7 | 5.07 |
| CL | Gagne, E.Gagne, Eric $ >> | 27 | 2003 | R | 100 | 59 | 0 | 5 | 6 | 2.98 | .264 | 1.06 | 6.6 | 3.0 | 12.3 | 60.1 | 44 | 20 | 20 | 6 | 20 | 82 | 0 | 36 | 4 | 0 | 0 | 1 | 0 | 2.62 |
| SU | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 89 | 61 | 0 | 7 | 2 | 2.58 | .274 | 1.12 | 7.0 | 3.1 | 9.7 | 66.1 | 51 | 21 | 19 | 7 | 23 | 71 | 0 | 3 | 7 | 0 | 0 | 1 | 0 | 3.32 |
| RP | Marte, D.Marte, Damaso $ >> | 28 | 2003 | L | 55 | 60 | 0 | 2 | 0 | 3.15 | .271 | 1.10 | 7.4 | 2.6 | 8.7 | 60.0 | 49 | 22 | 21 | 7 | 17 | 58 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 3.48 |
| RP | Linebrink, S.Linebrink, Scott >> | 28 | 2004 | R | 45 | 72 | 0 | 8 | 4 | 3.54 | .287 | 1.17 | 7.6 | 3.0 | 5.4 | 73.2 | 62 | 29 | 29 | 10 | 24 | 44 | 0 | 0 | 2 | 0 | 0 | 3 | 0 | 4.68 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 54 | 74 | 0 | 3 | 3 | 4.03 | .304 | 1.29 | 8.0 | 3.8 | 9.6 | 60.1 | 53 | 29 | 27 | 4 | 25 | 64 | 0 | 0 | 2 | 0 | 0 | 1 | 3 | 3.03 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 79 | 67 | 0 | 1 | 3 | 4.61 | .331 | 1.46 | 9.7 | 3.6 | 8.0 | 52.2 | 56 | 27 | 27 | 9 | 21 | 46 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.75 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 33 | 0 | 1 | 0 | 5.12 | .326 | 1.45 | 10.7 | 2.6 | 9.0 | 31.2 | 37 | 19 | 18 | 7 | 9 | 31 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.81 |