| SP | Liriano, F.Liriano, Francisco $$ >> | 23 | 2006 | L | 98 | 26 | 26 | 6 | 9 | 4.40 | .302 | 1.28 | 8.0 | 3.5 | 8.9 | 147.1 | 131 | 75 | 72 | 24 | 57 | 145 | 0 | 0 | 0 | 0 | 9 | 3 | 6 | 4.37 |
| SP | Carpenter, C.Carpenter, Chris # >> | 34 | 2009 | R | 80 | 25 | 25 | 10 | 9 | 4.39 | .295 | 1.23 | 9.3 | 1.8 | 7.0 | 149.2 | 154 | 73 | 73 | 21 | 30 | 116 | 0 | 0 | 0 | 0 | 15 | 4 | 2 | 3.96 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 25 | 25 | 11 | 5 | 4.97 | .315 | 1.35 | 9.2 | 3.0 | 6.6 | 145.0 | 148 | 81 | 80 | 28 | 48 | 107 | 0 | 0 | 0 | 0 | 11 | 4 | 1 | 5.11 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 24 | 24 | 9 | 6 | 4.98 | .339 | 1.46 | 10.1 | 3.2 | 6.0 | 151.2 | 169 | 86 | 84 | 23 | 53 | 100 | 0 | 0 | 0 | 0 | 14 | 11 | 2 | 4.93 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 23 | 23 | 10 | 9 | 5.57 | .336 | 1.47 | 9.9 | 3.3 | 7.0 | 129.1 | 142 | 81 | 80 | 24 | 48 | 100 | 0 | 0 | 0 | 0 | 10 | 6 | 2 | 5.12 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 67 | 0 | 4 | 1 | 2.18 | .303 | 1.24 | 4.8 | 6.3 | 9.0 | 78.1 | 42 | 22 | 19 | 3 | 55 | 78 | 0 | 4 | 4 | 0 | 0 | 5 | 0 | 3.81 |
| RP | Bailey, A.Bailey, Andrew $$ >> | 25 | 2009 | R | 85 | 56 | 0 | 5 | 3 | 3.94 | .330 | 1.38 | 9.3 | 3.2 | 8.6 | 61.2 | 63 | 30 | 27 | 9 | 22 | 58 | 0 | 6 | 2 | 0 | 0 | 6 | 1 | 4.39 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 58 | 0 | 2 | 4 | 4.46 | .321 | 1.35 | 8.9 | 3.4 | 7.6 | 72.2 | 71 | 37 | 36 | 10 | 27 | 61 | 0 | 5 | 3 | 0 | 0 | 5 | 1 | 4.44 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 54 | 0 | 1 | 4 | 6.86 | .365 | 1.67 | 11.3 | 3.9 | 7.5 | 60.1 | 75 | 46 | 46 | 14 | 26 | 50 | 0 | 3 | 2 | 0 | 0 | 3 | 0 | 5.82 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 90 | 31 | 0 | 4 | 0 | 3.97 | .320 | 1.38 | 8.5 | 4.0 | 7.9 | 34.0 | 32 | 16 | 15 | 2 | 15 | 30 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.41 |
| CL | Benitez, A.Benitez, Armando † >> | 32 | 2004 | R | 91 | 54 | 0 | 4 | 7 | 3.32 | .293 | 1.22 | 7.3 | 3.8 | 5.4 | 78.2 | 63 | 29 | 29 | 5 | 33 | 47 | 0 | 13 | 6 | 0 | 0 | 2 | 0 | 3.97 |