| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 97 | 12 | 12 | 6 | 3 | 2.64 | .239 | 0.92 | 6.1 | 2.2 | 7.0 | 81.2 | 55 | 24 | 24 | 6 | 20 | 63 | 0 | 0 | 0 | 0 | 10 | 2 | 2 | 3.22 |
| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 95 | 11 | 11 | 5 | 4 | 1.94 | .219 | 0.82 | 5.1 | 2.3 | 5.4 | 83.1 | 47 | 18 | 18 | 4 | 21 | 50 | 3 | 0 | 0 | 2 | 8 | 2 | 8 | 3.25 |
| SP | Lackey, J.Lackey, John >> | 38 | 2016 | R | 94 | 11 | 11 | 9 | 2 | 2.28 | .212 | 0.81 | 5.2 | 2.1 | 5.9 | 83.0 | 48 | 21 | 21 | 5 | 19 | 54 | 1 | 0 | 0 | 1 | 8 | 0 | 0 | 3.17 |
| SP | Hammel, J.Hammel, Jason >> | 34 | 2016 | R | 68 | 11 | 11 | 7 | 2 | 2.77 | .281 | 1.17 | 6.9 | 3.7 | 5.8 | 68.1 | 52 | 22 | 21 | 5 | 28 | 44 | 0 | 0 | 0 | 0 | 5 | 0 | 1 | 3.90 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 100 | 29 | 0 | 2 | 0 | 0.22 | .129 | 0.45 | 2.3 | 1.8 | 10.6 | 40.1 | 10 | 1 | 1 | 0 | 8 | 47 | 0 | 7 | 1 | 0 | 0 | 0 | 3 | 1.25 |
| RP | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 99 | 21 | 0 | 1 | 1 | 1.96 | .233 | 0.91 | 4.7 | 3.5 | 10.6 | 23.0 | 12 | 5 | 5 | 0 | 9 | 27 | 0 | 6 | 1 | 0 | 0 | 0 | 6 | 1.83 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 89 | 6 | 0 | 1 | 0 | 0.00 | .174 | 0.63 | 4.5 | 1.5 | 12.0 | 6.1 | 3 | 0 | 0 | 0 | 1 | 8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0.83 |
| RP | Montgomery, M.Montgomery, Mike >> | 26 | 2016 | L | 82 | 2 | 0 | 0 | 0 | 0.00 | .500 | 3.00 | 18.0 | 18.0 | 0.0 | 1.1 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9.00 |
| RP | Cahill, T.Cahill, Trevor >> | 28 | 2016 | R | 72 | 10 | 0 | 0 | 0 | 0.00 | .061 | 0.19 | 1.8 | 0.0 | 7.2 | 10.1 | 2 | 0 | 0 | 0 | 0 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.40 |