| SP | Arrieta, J.Arrieta, Jake $ >> | 29 | 2015 | R | 93 | 33 | 33 | 15 | 12 | 3.16 | .291 | 1.22 | 8.4 | 2.6 | 7.5 | 250.1 | 234 | 94 | 88 | 30 | 72 | 207 | 4 | 0 | 0 | 0 | 23 | 2 | 5 | 3.79 |
| SP | Maddux, G.Maddux, Greg † $ >> | 29 | 1995 | R | 89 | 32 | 32 | 13 | 14 | 4.01 | .294 | 1.24 | 9.5 | 1.7 | 5.5 | 224.2 | 236 | 111 | 100 | 22 | 43 | 137 | 6 | 0 | 0 | 0 | 17 | 1 | 4 | 3.64 |
| SP | Snell, B.Snell, Blake $ >> | 25 | 2018 | L | 80 | 32 | 32 | 14 | 8 | 3.58 | .284 | 1.16 | 6.7 | 3.8 | 9.0 | 196.0 | 146 | 84 | 78 | 26 | 82 | 197 | 3 | 0 | 0 | 3 | 15 | 5 | 6 | 4.05 |
| SP | Ryan, N.Ryan, Nolan $$ >> | 44 | 1991 | R | 73 | 31 | 31 | 14 | 12 | 4.09 | .295 | 1.23 | 7.2 | 3.9 | 7.3 | 207.0 | 165 | 96 | 94 | 22 | 90 | 168 | 1 | 0 | 0 | 0 | 17 | 5 | 5 | 4.14 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 14 | 7 | 2 | 2 | 3.67 | .331 | 1.48 | 7.2 | 6.2 | 8.7 | 61.1 | 49 | 27 | 25 | 6 | 42 | 59 | 0 | 0 | 1 | 0 | 4 | 0 | 0 | 4.41 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 39 | 0 | 1 | 3 | 3.94 | .262 | 1.06 | 6.9 | 2.6 | 6.8 | 48.0 | 37 | 21 | 21 | 7 | 14 | 36 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.27 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 6 | 0 | 0 | 1 | 3.18 | .292 | 1.24 | 10.8 | 1.8 | 7.2 | 5.2 | 6 | 3 | 2 | 1 | 1 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.60 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 26 | 0 | 3 | 2 | 3.40 | .353 | 1.64 | 9.7 | 5.3 | 6.9 | 39.2 | 42 | 17 | 15 | 2 | 23 | 30 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 3.90 |