| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 28 | 28 | 12 | 9 | 2.89 | .283 | 1.17 | 5.7 | 4.8 | 8.2 | 199.0 | 126 | 68 | 64 | 14 | 106 | 182 | 2 | 0 | 0 | 0 | 20 | 4 | 4 | 3.74 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 27 | 27 | 10 | 15 | 3.68 | .288 | 1.20 | 8.1 | 2.7 | 5.5 | 198.1 | 178 | 84 | 81 | 28 | 60 | 120 | 6 | 0 | 0 | 3 | 17 | 3 | 2 | 4.58 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 27 | 27 | 14 | 9 | 3.09 | .287 | 1.17 | 8.0 | 2.6 | 3.6 | 200.2 | 178 | 83 | 69 | 18 | 57 | 80 | 8 | 0 | 0 | 2 | 19 | 7 | 3 | 4.33 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 26 | 26 | 9 | 16 | 4.74 | .296 | 1.22 | 8.3 | 2.7 | 8.1 | 186.0 | 171 | 111 | 98 | 35 | 55 | 168 | 2 | 0 | 0 | 0 | 12 | 9 | 4 | 4.67 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 77 | 0 | 4 | 4 | 2.59 | .224 | 0.85 | 5.9 | 1.8 | 7.4 | 93.2 | 61 | 28 | 27 | 12 | 19 | 76 | 0 | 15 | 3 | 0 | 0 | 1 | 0 | 3.69 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 48 | 0 | 1 | 4 | 4.24 | .329 | 1.45 | 8.1 | 4.9 | 9.5 | 51.0 | 46 | 24 | 24 | 8 | 28 | 54 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 4.63 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 26 | 0 | 2 | 1 | 4.45 | .303 | 1.27 | 8.0 | 3.5 | 8.7 | 28.1 | 25 | 14 | 14 | 2 | 11 | 27 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 3.29 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 14 | 0 | 1 | 0 | 1.15 | .288 | 1.21 | 7.8 | 3.6 | 10.8 | 15.2 | 13 | 2 | 2 | 0 | 6 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.80 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 20 | 0 | 1 | 0 | 0.76 | .193 | 0.72 | 3.5 | 3.1 | 8.6 | 23.2 | 9 | 2 | 2 | 1 | 8 | 22 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.70 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 76 | 3 | 0 | 0 | 1 | 15.00 | .400 | 2.00 | 12.0 | 6.0 | 6.0 | 3.0 | 4 | 5 | 5 | 1 | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 8.00 |