| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 31 | 31 | 11 | 10 | 4.81 | .332 | 1.48 | 9.7 | 3.6 | 7.7 | 172.0 | 186 | 100 | 92 | 22 | 68 | 148 | 0 | 0 | 0 | 0 | 17 | 2 | 2 | 4.16 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 31 | 31 | 5 | 9 | 4.14 | .306 | 1.32 | 8.6 | 3.2 | 4.9 | 139.0 | 133 | 67 | 64 | 12 | 50 | 76 | 1 | 0 | 0 | 1 | 3 | 1 | 3 | 4.13 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 63 | 0 | 8 | 4 | 4.29 | .284 | 1.18 | 8.0 | 2.7 | 8.1 | 79.2 | 70 | 39 | 38 | 9 | 24 | 71 | 0 | 0 | 3 | 0 | 0 | 1 | 1 | 3.63 |
| RP | Williams, D.Williams, Devin $ >> | 28 | 2023 | R | 72 | 54 | 0 | 4 | 2 | 5.07 | .332 | 1.43 | 7.9 | 5.1 | 10.1 | 49.2 | 43 | 29 | 28 | 4 | 28 | 55 | 0 | 1 | 1 | 0 | 0 | 3 | 1 | 3.71 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 33 | 0 | 3 | 2 | 4.14 | .318 | 1.36 | 10.2 | 2.2 | 5.8 | 45.2 | 51 | 21 | 21 | 9 | 11 | 29 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 5.18 |
| CL | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 88 | 66 | 0 | 1 | 10 | 4.33 | .327 | 1.41 | 9.9 | 2.9 | 7.7 | 68.2 | 75 | 34 | 33 | 8 | 22 | 58 | 0 | 34 | 4 | 0 | 0 | 3 | 0 | 3.93 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 52 | 0 | 1 | 3 | 4.60 | .308 | 1.34 | 8.3 | 3.9 | 8.9 | 60.2 | 55 | 32 | 31 | 10 | 26 | 59 | 0 | 4 | 7 | 0 | 0 | 0 | 0 | 4.50 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 71 | 9 | 0 | 1 | 0 | 3.52 | .333 | 1.43 | 6.6 | 6.6 | 6.6 | 15.1 | 11 | 6 | 6 | 2 | 11 | 11 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 5.67 |