| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 29 | 29 | 14 | 7 | 3.55 | .284 | 1.17 | 7.6 | 3.0 | 7.7 | 175.0 | 147 | 70 | 69 | 19 | 58 | 149 | 1 | 0 | 0 | 0 | 17 | 3 | 4 | 3.75 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 28 | 28 | 14 | 5 | 2.50 | .251 | 0.98 | 6.9 | 2.0 | 4.8 | 201.1 | 154 | 61 | 56 | 16 | 44 | 107 | 4 | 0 | 0 | 3 | 23 | 4 | 1 | 3.69 |
| SP | Snell, B.Snell, Blake † >> | 25 | 2018 | L | 80 | 27 | 27 | 13 | 4 | 2.44 | .257 | 1.02 | 5.6 | 3.6 | 7.8 | 177.0 | 110 | 51 | 48 | 12 | 71 | 153 | 1 | 0 | 0 | 1 | 20 | 3 | 3 | 3.41 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 27 | 27 | 13 | 5 | 3.12 | .281 | 1.17 | 7.9 | 2.6 | 4.9 | 187.1 | 164 | 71 | 65 | 11 | 55 | 101 | 5 | 0 | 0 | 3 | 18 | 1 | 4 | 3.58 |
| SP | Lincecum, T.Lincecum, Tim # >> | 25 | 2009 | R | 39 | 26 | 25 | 12 | 8 | 4.15 | .322 | 1.38 | 9.0 | 3.5 | 8.2 | 147.1 | 147 | 70 | 68 | 12 | 57 | 134 | 2 | 0 | 0 | 0 | 14 | 6 | 7 | 3.52 |
| RP | Williams, D.Williams, Devin # >> | 28 | 2023 | R | 73 | 37 | 0 | 4 | 6 | 4.06 | .325 | 1.44 | 7.8 | 5.3 | 9.6 | 44.1 | 38 | 20 | 20 | 6 | 26 | 47 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 4.41 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 33 | 0 | 6 | 2 | 4.09 | .313 | 1.32 | 7.8 | 4.1 | 5.7 | 44.0 | 38 | 20 | 20 | 3 | 20 | 28 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 4.11 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 16 | 0 | 2 | 1 | 2.70 | .306 | 1.26 | 6.8 | 5.1 | 8.4 | 16.2 | 12 | 5 | 5 | 1 | 9 | 15 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 3.81 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 14 | 0 | 0 | 1 | 4.32 | .342 | 1.50 | 7.9 | 6.2 | 8.4 | 16.2 | 14 | 8 | 8 | 2 | 11 | 15 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 5.00 |