| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 15 | 15 | 2 | 9 | 5.97 | .341 | 1.54 | 11.0 | 2.9 | 8.9 | 75.1 | 92 | 67 | 50 | 18 | 24 | 74 | 1 | 0 | 0 | 1 | 4 | 1 | 0 | 5.15 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 14 | 14 | 6 | 6 | 4.34 | .306 | 1.31 | 8.1 | 3.7 | 7.9 | 87.0 | 78 | 46 | 42 | 9 | 36 | 76 | 1 | 0 | 0 | 0 | 6 | 1 | 2 | 3.87 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 14 | 14 | 5 | 5 | 5.87 | .313 | 1.33 | 9.5 | 2.6 | 4.5 | 76.2 | 80 | 52 | 50 | 18 | 22 | 38 | 3 | 0 | 0 | 0 | 6 | 3 | 1 | 6.07 |
| CL | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 34 | 0 | 3 | 3 | 4.11 | .301 | 1.29 | 6.8 | 4.9 | 9.0 | 50.1 | 38 | 23 | 23 | 5 | 27 | 50 | 0 | 13 | 1 | 0 | 0 | 0 | 0 | 3.92 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 41 | 0 | 1 | 2 | 4.56 | .314 | 1.35 | 7.5 | 4.8 | 7.7 | 47.1 | 39 | 28 | 24 | 6 | 25 | 40 | 0 | 1 | 4 | 0 | 0 | 1 | 0 | 4.62 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 34 | 0 | 0 | 2 | 4.68 | .317 | 1.39 | 8.1 | 4.5 | 7.7 | 42.1 | 38 | 22 | 22 | 3 | 21 | 36 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.71 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 25 | 0 | 3 | 1 | 5.40 | .359 | 1.62 | 8.2 | 6.5 | 7.9 | 33.1 | 30 | 20 | 20 | 6 | 24 | 29 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5.97 |