| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 99 | 33 | 33 | 13 | 10 | 4.49 | .307 | 1.32 | 8.4 | 3.5 | 7.4 | 226.1 | 210 | 118 | 113 | 22 | 89 | 187 | 2 | 0 | 0 | 1 | 21 | 2 | 6 | 3.82 |
| SP | Mathewson, C.Mathewson, Christy >> | 29 | 1909 | R | 91 | 33 | 33 | 11 | 18 | 4.37 | .303 | 1.27 | 9.1 | 2.3 | 4.2 | 245.1 | 249 | 133 | 119 | 25 | 63 | 115 | 9 | 0 | 0 | 1 | 18 | 8 | 7 | 4.26 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 87 | 32 | 32 | 14 | 16 | 4.98 | .336 | 1.48 | 9.7 | 3.6 | 4.8 | 227.2 | 244 | 138 | 126 | 24 | 92 | 120 | 4 | 0 | 0 | 0 | 12 | 9 | 5 | 4.65 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 79 | 32 | 32 | 9 | 13 | 4.57 | .329 | 1.42 | 9.3 | 3.5 | 7.6 | 222.2 | 230 | 122 | 113 | 27 | 86 | 187 | 1 | 0 | 0 | 0 | 14 | 11 | 3 | 4.21 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 89 | 73 | 0 | 4 | 2 | 3.46 | .294 | 1.24 | 9.9 | 1.4 | 7.1 | 80.2 | 88 | 31 | 31 | 7 | 12 | 63 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 3.05 |
| RP | Robertson, D.Robertson, David >> | 32 | 2017 | R | 87 | 25 | 0 | 1 | 1 | 4.70 | .274 | 1.13 | 6.7 | 3.5 | 10.2 | 23.0 | 17 | 12 | 12 | 4 | 9 | 26 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 4.17 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 82 | 15 | 0 | 0 | 0 | 2.93 | .333 | 1.50 | 10.2 | 3.6 | 8.4 | 15.1 | 17 | 5 | 5 | 1 | 6 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.20 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 78 | 16 | 0 | 0 | 0 | 6.75 | .444 | 2.33 | 17.3 | 4.2 | 6.2 | 13.1 | 25 | 10 | 10 | 2 | 6 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 5.23 |
| SU | Eckersley, D.Eckersley, Dennis # >> | 36 | 1990 | R | 91 | 49 | 0 | 0 | 4 | 5.06 | .294 | 1.21 | 8.8 | 2.1 | 8.3 | 48.0 | 47 | 27 | 27 | 2 | 11 | 44 | 0 | 1 | 9 | 0 | 0 | 2 | 0 | 2.52 |
| CL | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 96 | 66 | 0 | 9 | 4 | 1.73 | .261 | 1.00 | 5.4 | 3.8 | 9.9 | 72.2 | 43 | 15 | 14 | 0 | 30 | 79 | 0 | 42 | 3 | 0 | 0 | 4 | 1 | 2.22 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 72 | 2 | 0 | 0 | 0 | 6.30 | .286 | 1.20 | 8.1 | 2.7 | 4.5 | 10.0 | 9 | 7 | 7 | 2 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.50 |