| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 100 | 11 | 11 | 6 | 3 | 2.54 | .263 | 1.07 | 6.7 | 2.9 | 9.8 | 71.0 | 53 | 21 | 20 | 4 | 23 | 77 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 2.54 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 98 | 11 | 11 | 6 | 3 | 1.61 | .264 | 1.06 | 6.4 | 3.2 | 8.6 | 89.1 | 63 | 21 | 16 | 4 | 32 | 85 | 4 | 0 | 0 | 3 | 8 | 1 | 0 | 2.79 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 86 | 10 | 10 | 3 | 3 | 4.92 | .349 | 1.59 | 11.0 | 3.4 | 5.1 | 64.0 | 78 | 42 | 35 | 10 | 24 | 36 | 1 | 0 | 0 | 1 | 4 | 1 | 1 | 5.08 |
| SP | Strasburg, S.Strasburg, Stephen >> | 24 | 2013 | R | 71 | 11 | 11 | 6 | 3 | 4.73 | .313 | 1.37 | 8.9 | 3.5 | 7.6 | 66.2 | 65 | 35 | 35 | 12 | 26 | 56 | 0 | 0 | 0 | 0 | 6 | 0 | 1 | 4.85 |
| SP | Smith, E.Smith, Eddie # >> | 29 | 1942 | L | 10 | 8 | 8 | 5 | 0 | 3.88 | .350 | 1.60 | 9.3 | 5.2 | 5.2 | 55.2 | 57 | 27 | 24 | 7 | 32 | 32 | 0 | 0 | 0 | 0 | 5 | 1 | 1 | 5.29 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 29 | 0 | 3 | 0 | 1.82 | .207 | 0.76 | 6.0 | 0.9 | 9.5 | 39.2 | 26 | 8 | 8 | 3 | 4 | 41 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 2.28 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 90 | 26 | 0 | 3 | 2 | 5.08 | .318 | 1.40 | 9.3 | 3.5 | 4.6 | 33.2 | 34 | 20 | 19 | 5 | 13 | 17 | 0 | 5 | 1 | 0 | 0 | 0 | 1 | 5.12 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 89 | 18 | 0 | 1 | 1 | 3.38 | .309 | 1.29 | 8.5 | 3.5 | 8.0 | 18.2 | 17 | 7 | 7 | 3 | 7 | 16 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.72 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 65 | 13 | 0 | 1 | 0 | 4.50 | .344 | 1.57 | 12.2 | 1.9 | 11.6 | 14.0 | 19 | 9 | 7 | 2 | 3 | 18 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 2.93 |
| RP | McGowin, K.McGowin, Kyle >> | 29 | 2021 | R | 46 | 8 | 0 | 0 | 2 | 5.63 | .294 | 1.25 | 6.8 | 4.5 | 5.6 | 8.0 | 6 | 5 | 5 | 2 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.50 |
| RP | Roark, T.Roark, Tanner >> | 26 | 2013 | R | 56 | 14 | 2 | 0 | 1 | 4.74 | .337 | 1.42 | 8.5 | 4.3 | 6.2 | 19.0 | 18 | 10 | 10 | 2 | 9 | 13 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 4.74 |