| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 88 | 34 | 34 | 13 | 13 | 4.22 | .288 | 1.19 | 8.6 | 2.1 | 9.6 | 222.0 | 213 | 115 | 104 | 29 | 52 | 238 | 2 | 0 | 0 | 1 | 19 | 4 | 3 | 3.31 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 86 | 33 | 33 | 17 | 12 | 3.77 | .292 | 1.22 | 7.7 | 3.3 | 6.2 | 262.2 | 225 | 118 | 110 | 28 | 95 | 181 | 17 | 0 | 0 | 3 | 19 | 5 | 2 | 4.15 |
| SP | Verlander, J.Verlander, Justin >> | 28 | 2011 | R | 87 | 32 | 32 | 14 | 11 | 4.23 | .301 | 1.29 | 9.2 | 2.4 | 6.1 | 240.1 | 244 | 122 | 113 | 34 | 65 | 162 | 11 | 0 | 0 | 0 | 19 | 2 | 3 | 4.33 |
| SP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 80 | 32 | 32 | 0 | 8 | 2.08 | .250 | 0.99 | 6.8 | 2.1 | 5.1 | 91.0 | 69 | 24 | 21 | 2 | 21 | 52 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.87 |
| SP | Lolich, M.Lolich, Mickey # >> | 28 | 1968 | L | 63 | 33 | 31 | 12 | 10 | 4.67 | .302 | 1.28 | 9.0 | 2.6 | 6.1 | 190.2 | 190 | 103 | 99 | 34 | 54 | 129 | 0 | 1 | 0 | 0 | 18 | 4 | 2 | 4.88 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 87 | 79 | 0 | 14 | 3 | 4.02 | .290 | 1.19 | 8.0 | 2.6 | 9.2 | 85.0 | 76 | 38 | 38 | 8 | 25 | 87 | 0 | 3 | 2 | 0 | 0 | 3 | 0 | 3.16 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 78 | 84 | 0 | 2 | 2 | 3.90 | .336 | 1.52 | 8.7 | 5.1 | 8.7 | 64.2 | 62 | 30 | 28 | 7 | 36 | 62 | 0 | 2 | 4 | 0 | 0 | 0 | 5 | 4.17 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 72 | 78 | 0 | 0 | 2 | 4.48 | .305 | 1.29 | 8.2 | 3.5 | 5.4 | 78.1 | 71 | 41 | 39 | 9 | 30 | 47 | 0 | 5 | 2 | 0 | 0 | 2 | 8 | 4.53 |
| RP | Holton, T.Holton, Tyler # >> | 27 | 2023 | L | 74 | 81 | 0 | 4 | 3 | 5.15 | .338 | 1.48 | 10.5 | 2.9 | 4.6 | 71.2 | 83 | 43 | 41 | 12 | 23 | 36 | 0 | 4 | 6 | 0 | 0 | 4 | 3 | 5.32 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 67 | 60 | 0 | 2 | 3 | 3.70 | .347 | 1.55 | 7.2 | 6.8 | 9.0 | 41.1 | 33 | 17 | 17 | 3 | 31 | 41 | 0 | 3 | 2 | 0 | 0 | 2 | 2 | 4.37 |
| RP | Hernandez, W.Hernandez, Willie >> | 31 | 1985 | L | 56 | 59 | 0 | 2 | 5 | 5.37 | .310 | 1.27 | 10.4 | 1.1 | 5.0 | 63.2 | 73 | 39 | 38 | 13 | 8 | 35 | 0 | 15 | 5 | 0 | 0 | 5 | 0 | 5.19 |
| RP | Miller, S.Miller, Shelby >> | 33 | 2024 | R | 46 | 42 | 0 | 6 | 4 | 2.53 | .273 | 1.13 | 7.1 | 3.1 | 7.0 | 53.1 | 42 | 16 | 15 | 7 | 18 | 41 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 4.19 |