| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 97 | 15 | 15 | 8 | 2 | 2.85 | .269 | 1.08 | 7.1 | 2.7 | 10.2 | 98.0 | 77 | 32 | 31 | 10 | 29 | 111 | 0 | 0 | 0 | 0 | 11 | 2 | 0 | 3.01 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 90 | 14 | 14 | 5 | 6 | 4.02 | .329 | 1.44 | 8.9 | 4.1 | 8.7 | 105.1 | 104 | 47 | 47 | 8 | 48 | 101 | 3 | 0 | 0 | 1 | 7 | 3 | 3 | 3.52 |
| SP | Roark, T.Roark, Tanner >> | 26 | 2013 | R | 78 | 14 | 14 | 0 | 2 | 4.17 | .321 | 1.42 | 10.5 | 2.5 | 6.5 | 36.2 | 42 | 19 | 17 | 3 | 10 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.47 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 76 | 14 | 14 | 8 | 4 | 3.81 | .294 | 1.21 | 8.2 | 2.8 | 4.3 | 101.2 | 92 | 45 | 43 | 13 | 31 | 48 | 1 | 0 | 0 | 0 | 7 | 4 | 2 | 4.76 |
| SP | Martinez, D.Martinez, Dennis # >> | 37 | 1992 | R | 52 | 14 | 14 | 3 | 7 | 6.58 | .377 | 1.78 | 13.2 | 2.8 | 4.8 | 79.1 | 116 | 61 | 58 | 9 | 25 | 42 | 1 | 0 | 0 | 0 | 4 | 3 | 2 | 4.48 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 92 | 39 | 0 | 3 | 1 | 2.69 | .304 | 1.31 | 8.0 | 3.9 | 5.1 | 60.1 | 53 | 19 | 18 | 2 | 26 | 34 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 3.60 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 60 | 38 | 0 | 1 | 6 | 5.34 | .295 | 1.26 | 8.7 | 2.9 | 11.9 | 28.2 | 27 | 17 | 17 | 5 | 9 | 37 | 0 | 5 | 1 | 0 | 0 | 0 | 1 | 3.64 |
| RP | Rivero, F.Rivero, Felipe >> | 23 | 2015 | L | 42 | 42 | 0 | 3 | 1 | 3.91 | .250 | 1.00 | 6.7 | 2.3 | 7.4 | 23.0 | 17 | 10 | 10 | 3 | 6 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.83 |
| RP | Valdez, S.Valdez, Sergio >> | 28 | 1992 | R | 40 | 27 | 0 | 2 | 1 | 2.66 | .307 | 1.33 | 7.2 | 5.0 | 8.1 | 20.1 | 16 | 6 | 6 | 2 | 11 | 18 | 0 | 1 | 1 | 0 | 0 | 0 | 4 | 4.15 |
| RP | Kelley, S.Kelley, Shawn >> | 34 | 2018 | R | 35 | 15 | 0 | 1 | 0 | 2.65 | .250 | 0.94 | 6.4 | 2.1 | 12.7 | 17.0 | 12 | 6 | 5 | 1 | 4 | 24 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1.82 |
| CL | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 78 | 26 | 0 | 1 | 2 | 2.92 | .288 | 1.22 | 7.1 | 4.1 | 10.1 | 24.2 | 19 | 8 | 8 | 3 | 11 | 27 | 0 | 11 | 2 | 0 | 0 | 0 | 2 | 3.75 |
| SP | Strasburg, S.Strasburg, Stephen >> | 21 | 2010 | R | 47 | 16 | 0 | 2 | 2 | 9.00 | .393 | 1.94 | 12.3 | 5.1 | 8.2 | 35.0 | 48 | 35 | 35 | 8 | 20 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 5.86 |