| SP | Skubal, T.Skubal, Tarik † # >> | 28 | 2025 | L | 100 | 19 | 19 | 10 | 5 | 3.60 | .261 | 1.03 | 7.7 | 1.6 | 10.8 | 120.0 | 103 | 49 | 48 | 17 | 21 | 144 | 3 | 0 | 0 | 1 | 11 | 3 | 1 | 3.04 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 78 | 18 | 18 | 9 | 5 | 3.57 | .279 | 1.15 | 7.3 | 3.1 | 7.8 | 108.1 | 88 | 44 | 43 | 10 | 37 | 93 | 0 | 0 | 0 | 0 | 14 | 1 | 0 | 3.54 |
| SP | Kirby, G.Kirby, George >> | 27 | 2025 | R | 61 | 17 | 17 | 6 | 6 | 5.87 | .329 | 1.45 | 9.7 | 3.4 | 9.9 | 76.2 | 82 | 52 | 50 | 18 | 29 | 84 | 0 | 0 | 0 | 0 | 7 | 2 | 2 | 5.09 |
| SP | Woods Richardson, S.Woods Richardson, Simeon >> | 24 | 2025 | R | 56 | 17 | 17 | 3 | 3 | 5.12 | .337 | 1.51 | 9.8 | 3.9 | 7.7 | 77.1 | 84 | 45 | 44 | 18 | 33 | 66 | 0 | 0 | 0 | 0 | 3 | 1 | 3 | 5.65 |
| SP | Priester, Q.Priester, Quinn >> | 24 | 2025 | R | 48 | 17 | 17 | 1 | 6 | 6.13 | .369 | 1.72 | 11.5 | 4.1 | 8.1 | 83.2 | 106 | 59 | 57 | 13 | 38 | 75 | 0 | 0 | 0 | 0 | 4 | 3 | 4 | 4.71 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 100 | 53 | 0 | 5 | 3 | 4.29 | .305 | 1.25 | 7.6 | 3.7 | 11.4 | 63.0 | 53 | 30 | 30 | 10 | 26 | 80 | 0 | 0 | 0 | 0 | 0 | 4 | 4 | 3.95 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 84 | 49 | 0 | 3 | 2 | 3.15 | .306 | 1.31 | 8.2 | 3.7 | 11.7 | 54.1 | 49 | 20 | 19 | 5 | 22 | 70 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 2.89 |
| RP | Rogers, T.Rogers, Tyler >> | 34 | 2025 | R | 69 | 53 | 0 | 5 | 3 | 4.13 | .300 | 1.25 | 10.0 | 1.4 | 7.1 | 56.2 | 62 | 26 | 26 | 6 | 9 | 44 | 0 | 8 | 3 | 0 | 0 | 2 | 0 | 3.41 |
| RP | Hamilton, I.Hamilton, Ian >> | 30 | 2025 | R | 57 | 42 | 0 | 3 | 0 | 3.58 | .311 | 1.30 | 8.0 | 3.9 | 9.5 | 37.2 | 33 | 17 | 15 | 5 | 16 | 39 | 0 | 6 | 2 | 0 | 0 | 2 | 1 | 4.11 |
| RP | Gibson, C.Gibson, Cade >> | 27 | 2025 | L | 49 | 55 | 0 | 2 | 3 | 3.38 | .263 | 1.02 | 6.3 | 2.9 | 8.7 | 56.0 | 39 | 21 | 21 | 5 | 18 | 54 | 0 | 3 | 2 | 0 | 0 | 3 | 3 | 3.36 |