| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 11 | 11 | 6 | 4 | 4.16 | .314 | 1.35 | 9.4 | 2.8 | 9.5 | 71.1 | 74 | 33 | 33 | 8 | 22 | 75 | 0 | 0 | 0 | 0 | 7 | 2 | 0 | 3.37 |
| SP | Peralta, F.Peralta, Freddy >> | 29 | 2025 | R | 87 | 11 | 11 | 5 | 1 | 4.58 | .302 | 1.28 | 7.4 | 4.1 | 9.3 | 57.0 | 47 | 30 | 29 | 13 | 26 | 59 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 5.32 |
| SP | Schwellenbach, S.Schwellenbach, Spencer >> | 25 | 2025 | R | 85 | 11 | 11 | 6 | 3 | 4.59 | .320 | 1.31 | 9.8 | 2.1 | 7.9 | 68.2 | 74 | 35 | 35 | 12 | 16 | 60 | 1 | 0 | 0 | 0 | 6 | 7 | 1 | 4.54 |
| SP | Imanaga, S.Imanaga, Shota >> | 31 | 2025 | L | 81 | 11 | 11 | 4 | 3 | 3.95 | .317 | 1.33 | 9.0 | 3.0 | 7.9 | 66.0 | 66 | 29 | 29 | 5 | 22 | 58 | 0 | 0 | 0 | 0 | 7 | 4 | 0 | 3.41 |
| SP | Luzardo, J.Luzardo, Jesus # >> | 27 | 2025 | L | 64 | 11 | 11 | 4 | 1 | 4.19 | .293 | 1.19 | 8.2 | 2.6 | 10.8 | 66.2 | 60 | 32 | 31 | 7 | 19 | 79 | 0 | 0 | 0 | 0 | 6 | 4 | 0 | 3.03 |
| RP | Morejon, A.Morejon, Adrian >> | 26 | 2025 | L | 90 | 28 | 0 | 1 | 0 | 2.13 | .250 | 0.97 | 5.2 | 3.6 | 7.3 | 38.0 | 22 | 9 | 9 | 4 | 15 | 31 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.00 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 84 | 29 | 0 | 2 | 2 | 8.79 | .394 | 1.88 | 15.1 | 2.3 | 11.3 | 28.2 | 47 | 29 | 28 | 8 | 7 | 35 | 0 | 2 | 8 | 0 | 0 | 2 | 0 | 5.18 |
| RP | Kittredge, A.Kittredge, Andrew >> | 35 | 2025 | R | 84 | 16 | 0 | 2 | 1 | 3.57 | .321 | 1.42 | 9.5 | 3.7 | 10.1 | 17.2 | 18 | 7 | 7 | 2 | 7 | 19 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 3.53 |
| RP | Megill, T.Megill, Trevor >> | 31 | 2025 | R | 70 | 21 | 0 | 2 | 1 | 3.80 | .304 | 1.22 | 7.7 | 3.4 | 8.6 | 21.1 | 18 | 9 | 9 | 2 | 8 | 20 | 0 | 4 | 0 | 0 | 0 | 2 | 0 | 3.76 |
| RP | Hoffman, J.Hoffman, Jeff >> | 32 | 2025 | R | 60 | 17 | 0 | 0 | 0 | 3.92 | .319 | 1.35 | 9.0 | 3.6 | 9.9 | 20.2 | 20 | 9 | 9 | 4 | 8 | 22 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 4.75 |
| SP | Valdez, F.Valdez, Framber >> | 31 | 2025 | L | 59 | 2 | 0 | 0 | 1 | 4.15 | .316 | 1.38 | 11.3 | 2.3 | 11.3 | 4.1 | 5 | 2 | 2 | 0 | 1 | 5 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1.25 |
| CL | Okert, S.Okert, Steven >> | 33 | 2025 | L | 97 | 19 | 0 | 3 | 2 | 3.66 | .306 | 1.32 | 9.9 | 2.4 | 11.4 | 19.2 | 21 | 11 | 8 | 3 | 5 | 24 | 0 | 6 | 3 | 0 | 0 | 0 | 0 | 3.32 |