| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 26 | 26 | 13 | 2 | 2.75 | .260 | 1.04 | 6.7 | 2.7 | 10.5 | 183.1 | 136 | 56 | 56 | 20 | 54 | 214 | 0 | 0 | 0 | 0 | 21 | 3 | 0 | 3.02 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 88 | 25 | 25 | 12 | 5 | 3.86 | .313 | 1.35 | 9.2 | 3.0 | 9.5 | 158.2 | 162 | 70 | 68 | 24 | 52 | 166 | 1 | 0 | 0 | 0 | 16 | 3 | 5 | 3.92 |
| SP | Imanaga, S.Imanaga, Shota >> | 31 | 2025 | L | 81 | 24 | 24 | 8 | 5 | 2.67 | .260 | 1.02 | 7.4 | 1.7 | 7.2 | 162.0 | 134 | 50 | 48 | 13 | 31 | 130 | 0 | 0 | 0 | 0 | 18 | 6 | 4 | 3.12 |
| SP | Castillo, L.Castillo, Luis >> | 32 | 2025 | R | 62 | 26 | 23 | 10 | 8 | 5.06 | .326 | 1.42 | 9.6 | 3.2 | 8.9 | 128.0 | 137 | 76 | 72 | 22 | 45 | 127 | 1 | 2 | 0 | 0 | 10 | 4 | 2 | 4.40 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 100 | 88 | 0 | 6 | 0 | 2.21 | .268 | 1.04 | 5.6 | 3.8 | 11.5 | 69.1 | 43 | 19 | 17 | 7 | 29 | 88 | 0 | 8 | 1 | 0 | 0 | 4 | 3 | 3.20 |
| RP | Keller, B.Keller, Brad >> | 29 | 2025 | R | 91 | 81 | 0 | 5 | 3 | 2.25 | .280 | 1.14 | 7.0 | 3.3 | 9.9 | 72.0 | 56 | 20 | 18 | 3 | 26 | 79 | 0 | 1 | 4 | 0 | 0 | 2 | 4 | 2.51 |
| RP | Saalfrank, A.Saalfrank, Andrew >> | 27 | 2025 | L | 83 | 73 | 0 | 4 | 4 | 2.41 | .245 | 0.94 | 4.8 | 3.7 | 8.1 | 71.0 | 38 | 19 | 19 | 5 | 29 | 64 | 0 | 13 | 2 | 0 | 0 | 2 | 0 | 3.42 |
| RP | Whitlock, G.Whitlock, Garrett >> | 29 | 2025 | R | 75 | 66 | 0 | 6 | 4 | 2.42 | .284 | 1.17 | 8.0 | 2.7 | 9.8 | 70.2 | 62 | 19 | 19 | 5 | 21 | 76 | 0 | 9 | 5 | 0 | 0 | 1 | 0 | 2.70 |
| RP | Finnegan, K.Finnegan, Kyle >> | 33 | 2025 | R | 65 | 50 | 0 | 5 | 6 | 4.66 | .323 | 1.40 | 8.5 | 4.0 | 8.8 | 58.0 | 55 | 30 | 30 | 8 | 26 | 57 | 0 | 10 | 3 | 0 | 0 | 2 | 2 | 4.28 |