| SP | Maholm, P.Maholm, Paul >> | 23 | 2005 | L | 93 | 18 | 18 | 6 | 7 | 3.58 | .313 | 1.34 | 8.7 | 3.5 | 6.1 | 125.2 | 121 | 54 | 50 | 11 | 48 | 85 | 1 | 0 | 0 | 0 | 11 | 3 | 0 | 4.01 |
| SP | Arroyo, B.Arroyo, Bronson >> | 29 | 2006 | R | 87 | 18 | 18 | 8 | 5 | 5.05 | .316 | 1.38 | 9.9 | 2.5 | 7.2 | 114.0 | 125 | 72 | 64 | 16 | 32 | 91 | 1 | 0 | 0 | 0 | 6 | 1 | 2 | 4.10 |
| SP | Wakefield, T.Wakefield, Tim >> | 39 | 2005 | R | 75 | 17 | 17 | 9 | 3 | 3.73 | .322 | 1.36 | 8.5 | 3.8 | 5.6 | 115.2 | 108 | 49 | 48 | 9 | 49 | 71 | 0 | 0 | 0 | 0 | 11 | 8 | 7 | 4.27 |
| SU | Gonzalez, M.Gonzalez, Mike >> | 27 | 2005 | L | 84 | 34 | 0 | 1 | 2 | 2.48 | .258 | 1.01 | 6.2 | 3.1 | 9.0 | 32.2 | 22 | 12 | 9 | 0 | 11 | 32 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 2.13 |
| RP | Villone, R.Villone, Ron >> | 35 | 2005 | L | 61 | 25 | 0 | 3 | 3 | 4.03 | .343 | 1.57 | 8.2 | 6.1 | 9.0 | 22.1 | 20 | 11 | 10 | 2 | 15 | 22 | 0 | 1 | 2 | 0 | 0 | 0 | 4 | 4.23 |
| RP | Loaiza, E.Loaiza, Esteban >> | 34 | 2005 | R | 57 | 48 | 0 | 3 | 0 | 3.52 | .268 | 1.10 | 8.5 | 1.4 | 5.2 | 38.1 | 36 | 16 | 15 | 3 | 6 | 22 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.34 |
| RP | Sauerbeck, S.Sauerbeck, Scott >> | 34 | 2005 | L | 46 | 23 | 0 | 1 | 0 | 3.76 | .352 | 1.59 | 10.0 | 4.5 | 8.7 | 26.1 | 29 | 12 | 11 | 3 | 13 | 25 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.19 |
| SP | Benson, K.Benson, Kris >> | 31 | 2005 | R | 66 | 14 | 0 | 3 | 0 | 4.26 | .311 | 1.33 | 10.2 | 1.8 | 4.5 | 44.1 | 50 | 24 | 21 | 5 | 9 | 22 | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 4.16 |