| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 82 | 27 | 27 | 10 | 12 | 4.34 | .299 | 1.26 | 8.6 | 2.8 | 8.7 | 159.2 | 152 | 78 | 77 | 24 | 49 | 153 | 1 | 0 | 0 | 0 | 13 | 3 | 0 | 4.02 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 77 | 26 | 26 | 13 | 11 | 3.27 | .277 | 1.13 | 7.5 | 2.7 | 6.7 | 195.1 | 162 | 80 | 71 | 17 | 59 | 146 | 11 | 0 | 0 | 3 | 17 | 4 | 0 | 3.61 |
| SP | Scherzer, M.Scherzer, Max >> | 29 | 2013 | R | 71 | 25 | 25 | 5 | 11 | 4.95 | .328 | 1.45 | 9.9 | 3.2 | 7.9 | 143.2 | 158 | 83 | 79 | 15 | 51 | 126 | 3 | 0 | 0 | 1 | 11 | 1 | 7 | 3.69 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 69 | 25 | 25 | 4 | 11 | 5.66 | .339 | 1.52 | 10.7 | 3.1 | 8.6 | 109.2 | 129 | 75 | 69 | 24 | 38 | 104 | 0 | 0 | 0 | 0 | 7 | 2 | 3 | 5.06 |
| SP | Melton, T.Melton, Troy >> | 24 | 2025 | R | 63 | 25 | 25 | 1 | 3 | 4.87 | .353 | 1.62 | 9.2 | 5.5 | 5.6 | 77.2 | 79 | 44 | 42 | 12 | 47 | 48 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 5.65 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 76 | 68 | 0 | 6 | 1 | 2.70 | .284 | 1.15 | 6.2 | 4.2 | 7.5 | 93.1 | 64 | 28 | 28 | 6 | 43 | 77 | 0 | 7 | 1 | 0 | 0 | 4 | 0 | 3.70 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 57 | 61 | 0 | 11 | 5 | 3.88 | .322 | 1.40 | 8.2 | 4.4 | 5.4 | 102.0 | 93 | 51 | 44 | 11 | 50 | 61 | 0 | 5 | 7 | 0 | 0 | 2 | 8 | 4.74 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 63 | 52 | 0 | 3 | 3 | 3.70 | .308 | 1.30 | 6.4 | 5.4 | 9.0 | 58.1 | 41 | 25 | 24 | 9 | 35 | 58 | 0 | 9 | 4 | 0 | 0 | 2 | 1 | 4.93 |
| RP | Alburquerque, A.Alburquerque, Al >> | 25 | 2011 | R | 59 | 40 | 0 | 5 | 3 | 3.54 | .326 | 1.41 | 7.1 | 5.6 | 12.0 | 48.1 | 38 | 19 | 19 | 3 | 30 | 64 | 0 | 0 | 1 | 0 | 0 | 2 | 5 | 3.15 |
| RP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 51 | 45 | 0 | 1 | 2 | 2.57 | .276 | 1.13 | 7.9 | 2.3 | 6.2 | 84.0 | 74 | 27 | 24 | 6 | 21 | 58 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 3.33 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 54 | 30 | 0 | 4 | 0 | 2.97 | .232 | 0.85 | 4.3 | 3.5 | 8.5 | 36.1 | 17 | 12 | 12 | 6 | 14 | 34 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 4.61 |