| SP | Darvish, Y.Darvish, Yu >> | 35 | 2022 | R | 76 | 20 | 20 | 6 | 8 | 4.18 | .318 | 1.38 | 9.1 | 3.3 | 6.9 | 131.1 | 133 | 67 | 61 | 20 | 48 | 100 | 3 | 0 | 0 | 1 | 11 | 3 | 3 | 4.63 |
| SP | Paddack, C.Paddack, Chris # >> | 23 | 2019 | R | 68 | 19 | 19 | 9 | 4 | 3.47 | .304 | 1.30 | 8.3 | 3.5 | 8.8 | 111.2 | 102 | 44 | 43 | 7 | 43 | 109 | 0 | 0 | 0 | 0 | 9 | 1 | 2 | 3.05 |
| SP | Pivetta, N.Pivetta, Nick >> | 32 | 2025 | R | 75 | 19 | 19 | 6 | 9 | 4.35 | .311 | 1.34 | 9.2 | 2.9 | 7.5 | 111.2 | 114 | 54 | 54 | 10 | 36 | 93 | 0 | 0 | 0 | 0 | 8 | 1 | 3 | 3.50 |
| SP | Pomeranz, D.Pomeranz, Drew † >> | 27 | 2016 | L | 77 | 19 | 19 | 11 | 3 | 2.83 | .290 | 1.23 | 6.8 | 4.4 | 7.4 | 120.2 | 90 | 40 | 38 | 5 | 58 | 98 | 0 | 0 | 0 | 0 | 14 | 0 | 2 | 3.36 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 97 | 48 | 0 | 5 | 2 | 1.54 | .249 | 0.99 | 5.9 | 3.1 | 8.1 | 58.1 | 38 | 11 | 10 | 3 | 20 | 52 | 0 | 5 | 3 | 0 | 0 | 0 | 1 | 2.91 |
| RP | Meredith, C.Meredith, Cla >> | 23 | 2006 | R | 86 | 32 | 0 | 2 | 1 | 1.36 | .222 | 0.83 | 6.7 | 0.9 | 5.3 | 39.2 | 29 | 6 | 6 | 1 | 4 | 23 | 0 | 6 | 0 | 0 | 0 | 1 | 0 | 2.54 |
| RP | Benoit, J.Benoit, Joaquin >> | 37 | 2014 | R | 93 | 19 | 0 | 5 | 1 | 3.54 | .337 | 1.52 | 8.6 | 5.4 | 9.5 | 20.1 | 19 | 8 | 8 | 0 | 12 | 21 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.70 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 82 | 11 | 0 | 2 | 0 | 5.73 | .353 | 1.64 | 12.3 | 2.5 | 9.8 | 11.0 | 15 | 7 | 7 | 2 | 3 | 12 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Castillo, J.Castillo, Jose >> | 22 | 2018 | L | 75 | 19 | 0 | 1 | 1 | 7.29 | .364 | 1.62 | 10.3 | 4.3 | 9.9 | 21.0 | 24 | 18 | 17 | 3 | 10 | 23 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 4.38 |
| RP | Lamet, D.Lamet, Dinelson >> | 27 | 2020 | R | 85 | 13 | 0 | 1 | 1 | 2.73 | .261 | 1.03 | 6.3 | 3.0 | 9.3 | 33.0 | 23 | 10 | 10 | 1 | 11 | 34 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 2.42 |