| SP | Scherzer, M.Scherzer, Max # >> | 33 | 2017 | R | 98 | 18 | 18 | 7 | 6 | 3.77 | .293 | 1.22 | 8.2 | 2.8 | 8.6 | 121.2 | 110 | 54 | 51 | 11 | 38 | 116 | 1 | 0 | 0 | 0 | 12 | 3 | 1 | 3.28 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 92 | 19 | 19 | 6 | 9 | 4.03 | .314 | 1.37 | 8.9 | 3.4 | 9.2 | 145.0 | 144 | 65 | 65 | 20 | 54 | 149 | 6 | 0 | 0 | 1 | 10 | 1 | 4 | 3.88 |
| SP | Perez, P.Perez, Pascual # >> | 31 | 1988 | R | 80 | 18 | 18 | 5 | 8 | 6.02 | .346 | 1.59 | 10.6 | 3.8 | 5.5 | 110.2 | 130 | 74 | 74 | 13 | 46 | 67 | 1 | 0 | 0 | 1 | 7 | 0 | 5 | 4.57 |
| SP | Gonzalez, G.Gonzalez, Gio >> | 27 | 2012 | L | 51 | 18 | 18 | 5 | 7 | 4.83 | .339 | 1.53 | 8.6 | 5.2 | 7.6 | 108.0 | 103 | 65 | 58 | 11 | 62 | 91 | 0 | 0 | 0 | 0 | 10 | 1 | 4 | 4.39 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 56 | 0 | 1 | 1 | 3.09 | .271 | 1.09 | 7.2 | 2.6 | 6.9 | 35.0 | 28 | 12 | 12 | 6 | 10 | 27 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 4.63 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 89 | 60 | 0 | 1 | 5 | 5.35 | .310 | 1.32 | 6.9 | 5.2 | 7.1 | 38.2 | 29 | 24 | 23 | 4 | 22 | 30 | 0 | 6 | 2 | 0 | 0 | 1 | 1 | 4.61 |
| RP | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 74 | 41 | 0 | 2 | 3 | 7.85 | .344 | 1.57 | 10.6 | 3.9 | 7.7 | 28.2 | 33 | 25 | 25 | 6 | 12 | 24 | 0 | 3 | 5 | 0 | 0 | 0 | 1 | 5.36 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 67 | 39 | 0 | 3 | 2 | 3.65 | .315 | 1.32 | 8.8 | 3.2 | 11.2 | 37.0 | 36 | 15 | 15 | 6 | 13 | 46 | 0 | 3 | 1 | 0 | 0 | 2 | 2 | 3.84 |
| RP | Rivero, F.Rivero, Felipe >> | 23 | 2015 | L | 49 | 51 | 0 | 2 | 1 | 5.97 | .317 | 1.39 | 10.7 | 2.0 | 5.8 | 31.2 | 37 | 23 | 21 | 4 | 7 | 20 | 0 | 3 | 3 | 0 | 0 | 0 | 1 | 4.06 |
| RP | Wilson, J.Wilson, Justin >> | 28 | 2016 | L | 18 | 29 | 0 | 0 | 2 | 5.11 | .362 | 1.70 | 10.5 | 5.3 | 9.0 | 24.2 | 28 | 14 | 14 | 2 | 14 | 24 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 3.83 |