| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 89 | 9 | 9 | 5 | 1 | 2.85 | .257 | 1.01 | 7.2 | 1.9 | 8.7 | 66.1 | 53 | 21 | 21 | 5 | 14 | 64 | 0 | 0 | 0 | 0 | 7 | 2 | 1 | 2.77 |
| SP | Fister, D.Fister, Doug >> | 27 | 2011 | R | 86 | 9 | 9 | 0 | 1 | 4.50 | .265 | 1.04 | 8.3 | 1.1 | 6.8 | 24.0 | 22 | 12 | 12 | 2 | 3 | 18 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.08 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 85 | 9 | 9 | 4 | 4 | 3.95 | .276 | 1.10 | 7.3 | 2.6 | 5.4 | 68.1 | 55 | 30 | 30 | 6 | 20 | 41 | 5 | 0 | 0 | 1 | 6 | 3 | 1 | 3.96 |
| SP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 81 | 9 | 9 | 0 | 0 | 2.10 | .206 | 0.74 | 6.5 | 0.4 | 4.7 | 25.2 | 18 | 6 | 6 | 2 | 1 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.24 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 67 | 10 | 9 | 7 | 2 | 2.87 | .242 | 0.94 | 6.7 | 1.9 | 7.8 | 62.2 | 46 | 21 | 20 | 5 | 13 | 54 | 0 | 1 | 0 | 0 | 7 | 1 | 2 | 2.98 |
| RP | Holton, T.Holton, Tyler >> | 28 | 2024 | L | 88 | 23 | 0 | 8 | 2 | 1.87 | .207 | 0.78 | 5.2 | 1.9 | 4.6 | 43.1 | 25 | 10 | 9 | 3 | 9 | 22 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.51 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 90 | 21 | 0 | 2 | 0 | 1.53 | .235 | 0.89 | 5.0 | 3.1 | 8.1 | 29.1 | 16 | 5 | 5 | 0 | 10 | 26 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 2.34 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 69 | 21 | 0 | 4 | 3 | 2.74 | .234 | 0.89 | 5.8 | 2.4 | 5.8 | 42.2 | 27 | 13 | 13 | 5 | 11 | 27 | 0 | 5 | 1 | 0 | 0 | 1 | 1 | 4.12 |
| RP | Walker, J.Walker, Jamie >> | 31 | 2002 | L | 47 | 19 | 0 | 0 | 1 | 4.35 | .287 | 1.21 | 8.6 | 2.7 | 3.6 | 20.2 | 19 | 10 | 10 | 2 | 6 | 8 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 4.40 |
| RP | Hernandez, W.Hernandez, Willie >> | 31 | 1985 | L | 45 | 9 | 0 | 0 | 0 | 0.73 | .213 | 0.81 | 7.5 | 0.0 | 6.0 | 12.1 | 10 | 1 | 1 | 0 | 0 | 8 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1.67 |