| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 97 | 20 | 20 | 14 | 2 | 2.71 | .289 | 1.21 | 8.8 | 2.1 | 8.9 | 149.1 | 145 | 52 | 45 | 11 | 35 | 148 | 5 | 0 | 0 | 0 | 15 | 2 | 1 | 2.72 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 90 | 20 | 19 | 1 | 3 | 4.22 | .316 | 1.35 | 7.3 | 4.9 | 8.5 | 53.1 | 43 | 25 | 25 | 2 | 29 | 50 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3.36 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 81 | 18 | 18 | 6 | 7 | 4.51 | .338 | 1.51 | 9.2 | 4.5 | 7.2 | 129.2 | 132 | 72 | 65 | 14 | 64 | 103 | 4 | 0 | 0 | 1 | 8 | 3 | 2 | 4.37 |
| SP | Ramsdell, W.Ramsdell, Willie >> | 36 | 1952 | R | 76 | 21 | 20 | 0 | 1 | 3.88 | .310 | 1.35 | 8.8 | 3.4 | 4.8 | 53.1 | 52 | 23 | 23 | 2 | 20 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.57 |
| SP | Arrighetti, S.Arrighetti, Spencer >> | 24 | 2024 | R | 30 | 20 | 20 | 2 | 9 | 6.90 | .375 | 1.79 | 10.8 | 5.4 | 8.7 | 87.1 | 104 | 72 | 67 | 16 | 52 | 84 | 0 | 0 | 0 | 0 | 3 | 1 | 2 | 5.29 |
| RP | Kimbrel, C.Kimbrel, Craig † >> | 33 | 2021 | R | 100 | 55 | 0 | 13 | 2 | 3.42 | .291 | 1.17 | 4.4 | 6.2 | 9.4 | 68.1 | 33 | 28 | 26 | 5 | 47 | 71 | 0 | 1 | 3 | 0 | 0 | 4 | 0 | 4.12 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 94 | 53 | 0 | 6 | 3 | 3.84 | .304 | 1.28 | 5.8 | 5.7 | 11.1 | 68.0 | 44 | 32 | 29 | 5 | 43 | 84 | 0 | 7 | 3 | 0 | 0 | 2 | 6 | 3.47 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 88 | 43 | 0 | 6 | 1 | 2.83 | .301 | 1.27 | 7.1 | 4.4 | 9.5 | 57.1 | 45 | 21 | 18 | 4 | 28 | 60 | 0 | 4 | 2 | 0 | 0 | 1 | 1 | 3.33 |
| RP | Hodge, P.Hodge, Porter >> | 23 | 2024 | R | 80 | 43 | 0 | 4 | 0 | 2.72 | .259 | 1.05 | 6.1 | 3.4 | 8.2 | 56.1 | 38 | 17 | 17 | 3 | 21 | 51 | 0 | 8 | 2 | 0 | 0 | 0 | 2 | 3.00 |
| RP | Chafin, A.Chafin, Andrew >> | 31 | 2021 | L | 76 | 57 | 0 | 7 | 1 | 2.48 | .228 | 0.89 | 5.3 | 2.8 | 7.5 | 65.1 | 38 | 19 | 18 | 7 | 20 | 54 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 3.66 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 39 | 0 | 5 | 2 | 2.58 | .253 | 1.01 | 5.2 | 4.0 | 8.2 | 45.1 | 26 | 16 | 13 | 6 | 20 | 41 | 0 | 6 | 1 | 0 | 0 | 0 | 2 | 4.24 |
| RP | Wesneski, H.Wesneski, Hayden >> | 24 | 2022 | R | 49 | 28 | 0 | 1 | 1 | 2.77 | .284 | 1.17 | 6.4 | 4.3 | 6.9 | 48.2 | 34 | 17 | 15 | 3 | 23 | 37 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 3.77 |