| SP | Tiant, L.Tiant, Luis † >> | 28 | 1968 | R | 98 | 20 | 20 | 12 | 6 | 3.35 | .285 | 1.18 | 7.4 | 3.2 | 8.3 | 153.1 | 126 | 60 | 57 | 12 | 55 | 141 | 7 | 0 | 0 | 4 | 14 | 2 | 3 | 3.29 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 93 | 19 | 19 | 11 | 3 | 3.76 | .302 | 1.24 | 9.2 | 2.0 | 9.7 | 139.0 | 142 | 67 | 58 | 17 | 31 | 150 | 3 | 0 | 0 | 0 | 12 | 7 | 2 | 3.25 |
| SP | McKenzie, T.McKenzie, Triston # >> | 24 | 2022 | R | 79 | 19 | 19 | 11 | 2 | 4.18 | .310 | 1.30 | 9.0 | 2.8 | 7.6 | 122.2 | 122 | 57 | 57 | 17 | 38 | 103 | 0 | 0 | 0 | 0 | 11 | 5 | 4 | 4.18 |
| SP | Tomlin, J.Tomlin, Josh # >> | 26 | 2011 | R | 37 | 18 | 18 | 5 | 11 | 6.22 | .341 | 1.52 | 11.1 | 2.7 | 5.3 | 118.2 | 145 | 83 | 82 | 28 | 35 | 70 | 1 | 0 | 0 | 0 | 7 | 4 | 4 | 5.89 |
| SP | Donahue, R.Donahue, Red >> | 32 | 1905 | R | 29 | 18 | 18 | 5 | 7 | 6.77 | .394 | 1.92 | 13.3 | 4.1 | 4.0 | 114.1 | 168 | 88 | 86 | 18 | 52 | 51 | 0 | 0 | 0 | 0 | 6 | 3 | 0 | 5.61 |
| RP | Miller, A.Miller, Andrew † >> | 32 | 2017 | L | 86 | 47 | 0 | 4 | 0 | 1.36 | .240 | 0.92 | 4.6 | 3.7 | 10.1 | 66.1 | 34 | 12 | 10 | 3 | 27 | 74 | 0 | 6 | 3 | 0 | 0 | 2 | 2 | 2.67 |
| RP | Manship, J.Manship, Jeff >> | 30 | 2015 | R | 84 | 41 | 0 | 5 | 4 | 3.19 | .287 | 1.19 | 6.8 | 3.9 | 5.1 | 48.0 | 36 | 20 | 17 | 4 | 21 | 27 | 0 | 4 | 3 | 0 | 0 | 1 | 0 | 4.33 |
| RP | Perez, O.Perez, Oliver >> | 37 | 2018 | L | 93 | 31 | 0 | 4 | 1 | 1.90 | .290 | 1.23 | 9.0 | 2.3 | 9.8 | 23.2 | 23 | 7 | 5 | 0 | 6 | 25 | 0 | 6 | 2 | 0 | 0 | 0 | 1 | 1.61 |
| RP | Germano, J.Germano, Justin >> | 28 | 2010 | R | 39 | 4 | 0 | 0 | 1 | 15.00 | .400 | 2.00 | 12.0 | 6.0 | 6.0 | 3.0 | 4 | 5 | 5 | 1 | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 8.00 |
| RP | Sandlin, N.Sandlin, Nick >> | 24 | 2021 | R | 46 | 2 | 0 | 0 | 0 | 3.86 | .417 | 2.14 | 13.5 | 9.0 | 9.0 | 2.1 | 3 | 1 | 1 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Broxton, J.Broxton, Jonathan >> | 24 | 2008 | R | 35 | 4 | 0 | 0 | 0 | 3.38 | .273 | 1.13 | 9.0 | 1.8 | 7.2 | 5.1 | 5 | 2 | 2 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.00 |
| RP | Bieber, S.Bieber, Shane >> | 25 | 2020 | R | 75 | 17 | 0 | 1 | 1 | 3.69 | .308 | 1.33 | 9.5 | 2.5 | 10.2 | 39.0 | 41 | 16 | 16 | 6 | 11 | 44 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.59 |