| SP | Chamberlain, E.Chamberlain, Elton † | Cardinals | R | 162.0 | 23 | 21 | 16 | 2 | 2.28 | .257 | 1.02 | 6.6 | 2.7 | 5.1 | 193.2 | 141 | 51 | 49 | 14 | 57 | 109 | 14 | 0 | 0 | 5 | 16 | 3 | 0 | 3.75 |
| SP | Skubal, T.Skubal, Tarik † | Burners | L | 106.0 | 23 | 23 | 12 | 8 | 2.87 | .281 | 1.15 | 7.8 | 2.6 | 7.6 | 172.1 | 150 | 63 | 55 | 16 | 49 | 146 | 8 | 0 | 0 | 2 | 17 | 3 | 3 | 3.42 |
| SP | Steele, E.Steele, Elmer † | Red Sox | R | 105.0 | 22 | 22 | 13 | 5 | 3.28 | .274 | 1.13 | 8.3 | 1.9 | 4.8 | 173.0 | 159 | 64 | 63 | 14 | 36 | 92 | 8 | 0 | 0 | 2 | 16 | 1 | 0 | 3.63 |
| SP | Rogers, T.Rogers, Trevor † | O's | L | 101.0 | 22 | 22 | 14 | 3 | 3.37 | .284 | 1.18 | 7.8 | 2.9 | 7.2 | 149.2 | 129 | 57 | 56 | 12 | 48 | 120 | 1 | 0 | 0 | 0 | 14 | 1 | 0 | 3.42 |
| SP | Eovaldi, N.Eovaldi, Nathan | RyaNGers 982WAR | R | 92.0 | 22 | 22 | 13 | 7 | 3.30 | .280 | 1.14 | 8.3 | 2.0 | 7.3 | 155.2 | 143 | 64 | 57 | 11 | 34 | 125 | 2 | 0 | 0 | 0 | 17 | 5 | 6 | 3.06 |
| CL | Bautista, F.Bautista, Felix † | O's | R | 90.0 | 55 | 0 | 5 | 7 | 2.83 | .268 | 1.10 | 5.2 | 4.7 | 10.7 | 57.1 | 33 | 20 | 18 | 4 | 30 | 68 | 0 | 26 | 4 | 0 | 0 | 0 | 4 | 3.11 |
| RP | Helsley, R.Helsley, Ryan † # | Cardinals | R | 89.5 | 53 | 0 | 13 | 3 | 3.47 | .253 | 0.99 | 6.7 | 2.2 | 9.0 | 70.0 | 52 | 27 | 27 | 10 | 17 | 70 | 0 | 7 | 3 | 0 | 0 | 2 | 2 | 3.67 |