| SP | Chamberlain, E.Chamberlain, Elton † | Cardinals | R | 149.0 | 20 | 20 | 15 | 2 | 2.04 | .243 | 0.96 | 5.7 | 2.9 | 4.4 | 168.0 | 106 | 39 | 38 | 7 | 55 | 82 | 13 | 0 | 0 | 4 | 17 | 1 | 0 | 3.57 |
| RP | Helsley, R.Helsley, Ryan † | Cardinals | R | 83.0 | 43 | 0 | 11 | 3 | 1.71 | .241 | 0.95 | 4.6 | 4.0 | 8.6 | 68.1 | 35 | 16 | 13 | 7 | 30 | 65 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.75 |
| SP | Buchholz, C.Buchholz, Clay | Red Sox | R | 83.0 | 19 | 19 | 10 | 4 | 2.91 | .308 | 1.33 | 7.4 | 4.7 | 5.2 | 139.1 | 114 | 46 | 45 | 13 | 72 | 81 | 2 | 0 | 0 | 1 | 14 | 0 | 2 | 4.60 |
| SP | Verlander, J.Verlander, Justin | Astros | R | 80.0 | 20 | 20 | 11 | 3 | 3.62 | .271 | 1.11 | 7.5 | 2.5 | 9.2 | 134.1 | 112 | 57 | 54 | 15 | 37 | 137 | 0 | 0 | 0 | 0 | 13 | 1 | 5 | 3.26 |
| SP | Kershaw, C.Kershaw, Clayton † | Champions | L | 80.0 | 20 | 20 | 9 | 8 | 2.96 | .240 | 0.92 | 6.7 | 1.6 | 8.3 | 146.0 | 109 | 51 | 48 | 10 | 26 | 135 | 6 | 0 | 0 | 1 | 13 | 3 | 4 | 2.64 |
| SP | Coakley, A.Coakley, Andy # | Cubs | R | 80.0 | 19 | 19 | 8 | 6 | 2.90 | .275 | 1.12 | 8.0 | 2.1 | 6.6 | 155.0 | 138 | 52 | 50 | 16 | 36 | 113 | 5 | 0 | 0 | 2 | 12 | 2 | 1 | 3.62 |