| SP | McLain, D.McLain, Denny † | Rangers | R | 99.0 | 21 | 21 | 11 | 6 | 2.47 | .247 | 0.98 | 6.7 | 2.2 | 5.5 | 156.2 | 116 | 44 | 43 | 8 | 38 | 96 | 4 | 0 | 0 | 1 | 15 | 0 | 3 | 3.17 |
| SP | Kershaw, C.Kershaw, Clayton | Mets | L | 96.0 | 21 | 21 | 9 | 5 | 2.22 | .266 | 1.06 | 6.2 | 3.3 | 7.0 | 154.1 | 106 | 43 | 38 | 10 | 57 | 120 | 3 | 0 | 0 | 1 | 19 | 5 | 4 | 3.49 |
| SP | Johnson, R.Johnson, Randy † | Padres | L | 96.0 | 21 | 21 | 8 | 6 | 2.23 | .255 | 1.01 | 6.1 | 3.1 | 8.1 | 153.2 | 103 | 47 | 38 | 6 | 52 | 137 | 6 | 0 | 0 | 4 | 16 | 3 | 2 | 2.80 |
| SP | Martinez, P.Martinez, Pedro | Rangers | R | 93.0 | 21 | 21 | 10 | 8 | 2.56 | .238 | 0.92 | 5.7 | 2.6 | 7.3 | 158.0 | 100 | 46 | 45 | 9 | 46 | 129 | 5 | 0 | 0 | 2 | 16 | 2 | 0 | 3.02 |
| SP | Verlander, J.Verlander, Justin | Orioles | R | 86.0 | 21 | 21 | 11 | 5 | 3.06 | .273 | 1.08 | 6.9 | 2.9 | 5.1 | 144.1 | 110 | 55 | 49 | 10 | 46 | 81 | 4 | 0 | 0 | 0 | 16 | 7 | 4 | 3.88 |
| SP | deGrom, J.deGrom, Jacob † | Mets | R | 86.0 | 21 | 21 | 8 | 7 | 2.25 | .257 | 1.02 | 7.3 | 2.0 | 7.3 | 156.1 | 126 | 39 | 39 | 8 | 34 | 127 | 3 | 0 | 0 | 0 | 19 | 2 | 3 | 2.73 |
| CL | Clippard, T.Clippard, Tyler † | Orioles | R | 76.0 | 44 | 0 | 3 | 5 | 2.82 | .260 | 1.05 | 5.3 | 4.3 | 10.6 | 44.2 | 26 | 16 | 14 | 4 | 21 | 52 | 0 | 24 | 3 | 0 | 0 | 0 | 2 | 3.25 |