| SP | Hernandez, F.Hernandez, Felix † # $$ | Red Sox | R | 217.0 | 38 | 38 | 26 | 8 | 3.26 | .261 | 1.05 | 7.6 | 1.9 | 7.7 | 303.1 | 255 | 117 | 110 | 37 | 63 | 258 | 19 | 0 | 0 | 5 | 22 | 3 | 1 | 3.54 |
| SP | Porcello, R.Porcello, Rick † $$ | Astros | R | 168.0 | 34 | 34 | 20 | 10 | 2.99 | .252 | 1.01 | 6.7 | 2.4 | 5.7 | 268.0 | 200 | 95 | 89 | 30 | 70 | 170 | 13 | 0 | 0 | 2 | 23 | 1 | 4 | 3.98 |
| RP | Bailey, A.Bailey, Andrew † $$ | Red Sox | R | 152.5 | 90 | 0 | 10 | 3 | 2.51 | .218 | 0.83 | 5.6 | 1.9 | 9.2 | 129.1 | 80 | 38 | 36 | 13 | 27 | 132 | 0 | 27 | 5 | 0 | 0 | 1 | 3 | 2.91 |
| RP | Zumaya, J.Zumaya, Joel $$ | Royals | R | 151.5 | 97 | 0 | 13 | 3 | 2.96 | .274 | 1.12 | 7.3 | 2.8 | 9.8 | 161.0 | 130 | 58 | 53 | 14 | 50 | 176 | 0 | 19 | 5 | 0 | 0 | 2 | 9 | 2.91 |
| RP | Fruto, E.Fruto, Emiliano † $$ | Indians | R | 148.5 | 88 | 0 | 14 | 4 | 2.52 | .260 | 1.05 | 6.7 | 2.8 | 10.3 | 178.1 | 133 | 56 | 50 | 17 | 55 | 203 | 0 | 11 | 5 | 0 | 0 | 0 | 11 | 2.89 |
| SP | Strasburg, S.Strasburg, Stephen # $$ | Mariners | R | 128.0 | 34 | 34 | 17 | 8 | 3.81 | .269 | 1.10 | 7.1 | 2.8 | 10.2 | 238.2 | 189 | 104 | 101 | 25 | 73 | 270 | 4 | 0 | 0 | 2 | 21 | 1 | 7 | 3.03 |
| SP | Kluber, C.Kluber, Corey $$ | Astros | R | 118.0 | 35 | 35 | 15 | 14 | 3.39 | .275 | 1.11 | 7.7 | 2.4 | 6.9 | 246.2 | 210 | 100 | 93 | 30 | 65 | 189 | 9 | 0 | 0 | 4 | 22 | 5 | 6 | 3.90 |
| SP | Bumgarner, M.Bumgarner, Madison $$ | Rays | L | 117.0 | 33 | 33 | 12 | 10 | 3.34 | .267 | 1.08 | 7.5 | 2.2 | 7.8 | 258.1 | 214 | 98 | 96 | 34 | 64 | 223 | 9 | 0 | 0 | 3 | 19 | 4 | 5 | 3.78 |