| SP | Arrieta, J.Arrieta, Jake † | Brau | R | 195.0 | 38 | 38 | 21 | 14 | 2.54 | .247 | 0.96 | 5.8 | 2.9 | 7.7 | 290.1 | 186 | 86 | 82 | 23 | 94 | 248 | 12 | 0 | 0 | 7 | 27 | 5 | 4 | 3.34 |
| SP | Martinez, P.Martinez, Pedro † | Corporation | R | 167.0 | 34 | 34 | 16 | 13 | 2.48 | .247 | 0.97 | 6.4 | 2.3 | 10.1 | 264.2 | 189 | 78 | 73 | 24 | 67 | 295 | 11 | 0 | 0 | 5 | 24 | 4 | 1 | 2.75 |
| RP | Chapman, A.Chapman, Aroldis † | Time | L | 126.0 | 103 | 0 | 16 | 1 | 1.87 | .248 | 0.93 | 4.5 | 3.8 | 10.7 | 101.1 | 51 | 21 | 21 | 7 | 43 | 120 | 0 | 2 | 2 | 0 | 0 | 6 | 4 | 2.98 |
| CL | Hochevar, L.Hochevar, Luke † | Chiefs | R | 122.5 | 82 | 0 | 2 | 6 | 2.96 | .255 | 0.95 | 5.8 | 2.7 | 9.4 | 76.0 | 49 | 25 | 25 | 11 | 23 | 79 | 0 | 43 | 6 | 0 | 0 | 6 | 4 | 3.95 |
| RP | Williams, D.Williams, Devin | Time | R | 120.5 | 101 | 0 | 18 | 4 | 2.84 | .271 | 1.06 | 5.1 | 4.4 | 10.0 | 114.0 | 65 | 38 | 36 | 8 | 56 | 127 | 0 | 1 | 1 | 0 | 0 | 6 | 2 | 3.32 |
| SP | Higuera, T.Higuera, Teddy | Butts | L | 119.5 | 34 | 31 | 15 | 10 | 3.30 | .277 | 1.14 | 7.9 | 2.3 | 6.9 | 218.0 | 192 | 80 | 80 | 33 | 56 | 166 | 8 | 1 | 0 | 0 | 21 | 2 | 0 | 4.24 |