| SP | Arrieta, J.Arrieta, Jake † | Brau | R | 151.0 | 28 | 28 | 15 | 10 | 2.27 | .247 | 0.96 | 5.7 | 3.0 | 7.5 | 217.2 | 138 | 59 | 55 | 14 | 72 | 180 | 10 | 0 | 0 | 6 | 21 | 4 | 2 | 3.23 |
| SP | Martinez, P.Martinez, Pedro † | Corporation | R | 141.0 | 28 | 28 | 13 | 11 | 2.26 | .249 | 0.98 | 6.6 | 2.3 | 9.9 | 219.0 | 160 | 60 | 55 | 17 | 55 | 242 | 9 | 0 | 0 | 3 | 21 | 3 | 1 | 2.59 |
| CL | Kimbrel, C.Kimbrel, Craig † | Corporation | R | 114.0 | 55 | 0 | 1 | 2 | 2.02 | .261 | 1.03 | 6.2 | 3.0 | 9.4 | 62.1 | 43 | 15 | 14 | 5 | 21 | 65 | 0 | 36 | 2 | 0 | 0 | 2 | 4 | 3.06 |
| SP | Higuera, T.Higuera, Teddy | Butts | L | 112.0 | 27 | 26 | 13 | 7 | 2.91 | .269 | 1.09 | 7.4 | 2.5 | 7.0 | 185.2 | 152 | 60 | 60 | 26 | 51 | 144 | 7 | 0 | 0 | 0 | 19 | 2 | 0 | 4.13 |
| RP | Chapman, A.Chapman, Aroldis † | Time | L | 102.0 | 81 | 0 | 12 | 1 | 1.51 | .237 | 0.86 | 4.0 | 3.8 | 11.1 | 83.2 | 37 | 14 | 14 | 5 | 35 | 102 | 0 | 2 | 1 | 0 | 0 | 6 | 2 | 2.81 |
| CL | Hochevar, L.Hochevar, Luke † | Chiefs | R | 100.5 | 68 | 0 | 2 | 5 | 3.16 | .248 | 0.89 | 5.5 | 2.6 | 9.6 | 62.2 | 38 | 22 | 22 | 9 | 18 | 66 | 0 | 35 | 4 | 0 | 0 | 6 | 3 | 3.92 |