| SP | Arrieta, J.Arrieta, Jake † | Brau | R | 177.0 | 34 | 34 | 18 | 13 | 2.41 | .243 | 0.94 | 5.6 | 3.0 | 7.5 | 265.2 | 164 | 75 | 71 | 21 | 87 | 222 | 12 | 0 | 0 | 7 | 25 | 5 | 2 | 3.40 |
| SP | Martinez, P.Martinez, Pedro † | Corporation | R | 167.0 | 34 | 34 | 16 | 13 | 2.48 | .247 | 0.97 | 6.4 | 2.3 | 10.1 | 264.2 | 189 | 78 | 73 | 24 | 67 | 295 | 11 | 0 | 0 | 5 | 24 | 4 | 1 | 2.75 |
| SP | Higuera, T.Higuera, Teddy | Butts | L | 122.5 | 33 | 31 | 15 | 9 | 3.24 | .276 | 1.14 | 7.9 | 2.3 | 6.9 | 216.2 | 190 | 78 | 78 | 32 | 56 | 166 | 8 | 1 | 0 | 0 | 21 | 2 | 0 | 4.19 |
| CL | Hochevar, L.Hochevar, Luke † | Chiefs | R | 121.5 | 81 | 0 | 2 | 6 | 3.01 | .256 | 0.95 | 5.8 | 2.8 | 9.6 | 74.2 | 48 | 25 | 25 | 11 | 23 | 79 | 0 | 43 | 6 | 0 | 0 | 6 | 4 | 3.97 |
| RP | Chapman, A.Chapman, Aroldis † | Time | L | 118.0 | 98 | 0 | 15 | 1 | 1.86 | .246 | 0.92 | 4.5 | 3.8 | 10.7 | 97.0 | 48 | 20 | 20 | 6 | 41 | 115 | 0 | 2 | 2 | 0 | 0 | 6 | 4 | 2.89 |
| CL | Kimbrel, C.Kimbrel, Craig † | Corporation | R | 116.5 | 61 | 0 | 1 | 3 | 2.53 | .283 | 1.14 | 6.7 | 3.6 | 9.3 | 67.2 | 50 | 20 | 19 | 6 | 27 | 69 | 0 | 39 | 3 | 0 | 0 | 3 | 4 | 3.45 |