| SP | Martinez, P.Martinez, Pedro † # | Warriors | R | 129.0 | 26 | 26 | 14 | 9 | 3.03 | .248 | 0.97 | 7.2 | 1.6 | 11.0 | 201.2 | 160 | 72 | 68 | 26 | 35 | 246 | 12 | 0 | 0 | 2 | 17 | 4 | 3 | 2.82 |
| SP | Hernandez, F.Hernandez, Felix | Miners | R | 103.0 | 26 | 26 | 14 | 7 | 3.62 | .262 | 1.05 | 6.9 | 2.5 | 7.0 | 191.1 | 146 | 79 | 77 | 24 | 54 | 148 | 5 | 0 | 0 | 1 | 17 | 4 | 3 | 3.99 |
| SP | Halladay, R.Halladay, Roy $ | Nuked Hotdogs | R | 103.0 | 25 | 25 | 14 | 5 | 3.86 | .294 | 1.24 | 9.3 | 1.8 | 7.2 | 186.1 | 193 | 86 | 80 | 22 | 38 | 148 | 6 | 0 | 0 | 2 | 15 | 2 | 6 | 3.59 |
| SP | Santana, J.Santana, Johan | Tettigoniidae | L | 103.0 | 26 | 26 | 12 | 7 | 3.09 | .296 | 1.24 | 8.0 | 3.1 | 10.0 | 186.2 | 166 | 69 | 64 | 17 | 65 | 207 | 1 | 0 | 0 | 0 | 18 | 5 | 7 | 3.09 |
| SP | Lincecum, T.Lincecum, Tim # | Skeletons | R | 98.0 | 26 | 26 | 11 | 9 | 3.07 | .266 | 1.07 | 6.8 | 2.8 | 9.4 | 190.1 | 144 | 67 | 65 | 17 | 60 | 199 | 4 | 0 | 0 | 1 | 17 | 3 | 7 | 3.06 |
| SP | Vazquez, J.Vazquez, Javier # | Red Sox | R | 94.0 | 25 | 25 | 15 | 6 | 4.17 | .277 | 1.12 | 8.0 | 2.1 | 9.5 | 168.1 | 149 | 82 | 78 | 22 | 40 | 177 | 2 | 0 | 0 | 0 | 16 | 4 | 1 | 3.38 |
| SP | Perez, O.Perez, Oliver $$ | Red Sox | L | 84.0 | 25 | 25 | 13 | 8 | 3.84 | .307 | 1.31 | 8.1 | 3.7 | 9.7 | 159.1 | 143 | 70 | 68 | 29 | 65 | 171 | 1 | 0 | 0 | 0 | 16 | 4 | 5 | 4.52 |