| CL | Papelbon, J.Papelbon, Jonathan † $ | Fishermen | R | 140.5 | 99 | 0 | 7 | 7 | 3.73 | .285 | 1.19 | 7.7 | 3.0 | 8.0 | 111.0 | 95 | 47 | 46 | 12 | 37 | 99 | 0 | 41 | 6 | 0 | 0 | 1 | 6 | 3.65 |
| SP | Halladay, R.Halladay, Roy $ | Nuked Hotdogs | R | 137.0 | 36 | 36 | 19 | 14 | 3.70 | .284 | 1.16 | 8.2 | 2.2 | 6.1 | 275.0 | 252 | 115 | 113 | 35 | 68 | 185 | 12 | 0 | 0 | 4 | 18 | 7 | 2 | 4.13 |
| SP | Santana, J.Santana, Johan † $ | Bears | L | 135.0 | 37 | 37 | 18 | 13 | 3.41 | .290 | 1.18 | 7.3 | 3.3 | 8.9 | 248.0 | 202 | 99 | 94 | 31 | 91 | 245 | 5 | 0 | 0 | 3 | 23 | 11 | 4 | 3.88 |
| CL | Balfour, G.Balfour, Grant | Ducks | R | 116.5 | 92 | 0 | 6 | 5 | 4.11 | .341 | 1.52 | 7.3 | 6.4 | 9.4 | 92.0 | 75 | 46 | 42 | 11 | 65 | 96 | 0 | 33 | 3 | 0 | 0 | 3 | 1 | 4.68 |
| SP | Lincecum, T.Lincecum, Tim # $$ | Nuked Hotdogs | R | 113.0 | 38 | 38 | 17 | 17 | 3.96 | .303 | 1.27 | 8.5 | 3.0 | 9.0 | 265.2 | 251 | 123 | 117 | 27 | 87 | 266 | 7 | 0 | 0 | 3 | 21 | 9 | 8 | 3.40 |
| SP | Schilling, C.Schilling, Curt † | Warriors | R | 107.0 | 36 | 36 | 13 | 13 | 3.72 | .282 | 1.14 | 8.2 | 2.1 | 10.0 | 256.1 | 232 | 112 | 106 | 37 | 60 | 284 | 7 | 0 | 0 | 2 | 22 | 10 | 6 | 3.48 |
| SP | Johnson, R.Johnson, Randy | Fishermen | L | 106.0 | 39 | 39 | 15 | 14 | 4.00 | .292 | 1.21 | 7.7 | 3.2 | 8.9 | 268.0 | 228 | 124 | 119 | 32 | 96 | 266 | 6 | 0 | 0 | 2 | 21 | 7 | 7 | 3.72 |