| SP | Scherzer, M.Scherzer, Max † | Senators | R | 145.0 | 32 | 32 | 17 | 8 | 3.15 | .266 | 1.08 | 7.2 | 2.6 | 8.4 | 239.2 | 190 | 93 | 84 | 29 | 68 | 223 | 7 | 0 | 0 | 3 | 23 | 3 | 5 | 3.60 |
| SP | Lincecum, T.Lincecum, Tim † | Tigers | R | 130.0 | 32 | 32 | 20 | 6 | 4.34 | .301 | 1.27 | 7.6 | 3.8 | 8.8 | 230.1 | 195 | 122 | 111 | 32 | 98 | 225 | 5 | 0 | 0 | 3 | 15 | 5 | 8 | 4.20 |
| CL | Chapman, A.Chapman, Aroldis † | Reds | L | 129.5 | 68 | 0 | 3 | 9 | 4.41 | .280 | 1.15 | 7.0 | 3.4 | 9.4 | 69.1 | 54 | 35 | 34 | 10 | 26 | 72 | 0 | 51 | 5 | 0 | 0 | 1 | 3 | 3.97 |
| SP | Hendrix, C.Hendrix, Claude † | Tigers | R | 126.0 | 32 | 32 | 20 | 5 | 4.54 | .301 | 1.26 | 8.7 | 2.6 | 4.8 | 246.0 | 239 | 131 | 124 | 25 | 71 | 132 | 12 | 0 | 0 | 1 | 16 | 8 | 5 | 4.21 |
| SP | Johnson, W.Johnson, Walter | Senators | R | 123.0 | 33 | 33 | 15 | 14 | 3.55 | .268 | 1.09 | 8.4 | 1.5 | 5.6 | 269.0 | 250 | 114 | 106 | 32 | 44 | 168 | 17 | 0 | 0 | 2 | 17 | 2 | 0 | 3.81 |
| SP | Corbin, P.Corbin, Patrick | Senators | L | 118.0 | 32 | 32 | 17 | 9 | 3.44 | .307 | 1.33 | 8.5 | 3.5 | 8.3 | 206.2 | 194 | 86 | 79 | 30 | 80 | 190 | 1 | 0 | 0 | 0 | 22 | 1 | 2 | 4.23 |