| SP | Hunter, R.Hunter, Rich † + | White Sox | R | 151.0 | 21 | 21 | 16 | 4 | 1.84 | .228 | 0.84 | 5.9 | 1.7 | 6.2 | 171.1 | 112 | 37 | 35 | 7 | 32 | 118 | 10 | 0 | 0 | 0 | 18 | 8 | 4 | 2.85 |
| SP | Haynes, J.Haynes, Jimmy † + | Orioles | R | 130.0 | 22 | 22 | 13 | 3 | 2.71 | .273 | 1.09 | 5.6 | 4.2 | 8.9 | 179.1 | 112 | 54 | 54 | 10 | 83 | 178 | 9 | 0 | 0 | 3 | 15 | 7 | 0 | 3.25 |
| SP | Sampson, B.Sampson, Benj † + | Twins | L | 122.0 | 22 | 22 | 13 | 3 | 2.41 | .252 | 1.01 | 5.8 | 3.3 | 9.6 | 153.0 | 98 | 42 | 41 | 13 | 56 | 164 | 3 | 0 | 0 | 3 | 15 | 1 | 12 | 3.08 |
| SP | Santana, J.Santana, Johan | Twins | L | 106.0 | 22 | 22 | 11 | 4 | 2.95 | .270 | 1.09 | 7.8 | 2.0 | 9.3 | 165.0 | 143 | 54 | 54 | 10 | 37 | 170 | 6 | 0 | 0 | 2 | 14 | 3 | 3 | 2.45 |
| CL | Soriano, R.Soriano, Rafael † | Mariners | R | 93.5 | 34 | 0 | 2 | 1 | 1.75 | .250 | 0.97 | 6.0 | 2.8 | 10.0 | 36.0 | 24 | 7 | 7 | 2 | 11 | 40 | 0 | 29 | 3 | 0 | 0 | 1 | 0 | 2.50 |
| SP | Halladay, R.Halladay, Roy + | Blue Jays | R | 90.0 | 20 | 20 | 8 | 7 | 2.54 | .260 | 1.04 | 7.8 | 1.6 | 6.2 | 166.1 | 143 | 51 | 47 | 19 | 30 | 114 | 9 | 0 | 0 | 1 | 16 | 2 | 3 | 3.69 |