| SP | Collins, R.Collins, Ray BOS † | Red Sox | L | 189.0 | 35 | 35 | 23 | 3 | 2.83 | .271 | 1.11 | 7.8 | 2.2 | 5.1 | 254.1 | 220 | 95 | 80 | 24 | 62 | 143 | 6 | 0 | 0 | 2 | 27 | 1 | 4 | 3.85 |
| SP | Crochet, G.Crochet, Garrett BOS † | Red Sox | L | 183.0 | 36 | 36 | 23 | 7 | 2.79 | .265 | 1.07 | 6.5 | 3.1 | 8.4 | 245.1 | 178 | 83 | 76 | 11 | 85 | 229 | 2 | 0 | 0 | 1 | 28 | 2 | 4 | 2.78 |
| SP | Waddell, R.Waddell, Rube CHC | Cubs | L | 159.0 | 33 | 33 | 18 | 11 | 2.98 | .302 | 1.28 | 8.9 | 2.7 | 6.0 | 259.2 | 255 | 97 | 86 | 18 | 77 | 172 | 15 | 0 | 0 | 5 | 20 | 5 | 3 | 3.53 |
| SP | Cone, D.Cone, David NYY † # | Yankees | R | 144.0 | 34 | 34 | 22 | 9 | 3.87 | .284 | 1.18 | 7.6 | 3.0 | 7.9 | 237.1 | 201 | 106 | 102 | 23 | 79 | 208 | 6 | 0 | 0 | 0 | 21 | 3 | 5 | 3.54 |
| SP | Koufax, S.Koufax, Sandy LA † | Dodgers | L | 143.0 | 32 | 32 | 16 | 7 | 2.89 | .268 | 1.08 | 7.2 | 2.5 | 8.4 | 227.0 | 182 | 78 | 73 | 14 | 63 | 212 | 4 | 0 | 0 | 3 | 25 | 4 | 10 | 2.82 |
| SP | Bender, C.Bender, Chief OAK | Athletics | R | 137.0 | 33 | 33 | 18 | 10 | 3.20 | .282 | 1.17 | 7.8 | 2.7 | 5.4 | 245.0 | 213 | 90 | 87 | 11 | 73 | 147 | 5 | 0 | 0 | 1 | 20 | 3 | 3 | 3.31 |
| CL | Jansen, K.Jansen, Kenley BOS † | Red Sox | R | 136.0 | 70 | 0 | 2 | 4 | 2.17 | .248 | 0.98 | 5.5 | 3.4 | 6.7 | 74.2 | 45 | 20 | 18 | 6 | 28 | 55 | 0 | 44 | 3 | 0 | 0 | 1 | 0 | 3.74 |
| SP | Kershaw, C.Kershaw, Clayton LA | Dodgers | L | 132.0 | 33 | 33 | 17 | 10 | 2.69 | .277 | 1.14 | 7.7 | 2.6 | 7.7 | 207.2 | 177 | 67 | 62 | 9 | 60 | 178 | 0 | 0 | 0 | 0 | 21 | 2 | 0 | 2.74 |
| CL | Eckersley, D.Eckersley, Dennis CLE † | Indians | R | 127.5 | 73 | 0 | 3 | 10 | 4.12 | .321 | 1.39 | 10.3 | 2.3 | 9.1 | 67.2 | 77 | 31 | 31 | 5 | 17 | 68 | 0 | 49 | 1 | 0 | 0 | 2 | 0 | 2.79 |
| CL | Jansen, K.Jansen, Kenley LA † | Dodgers | R | 123.5 | 71 | 0 | 6 | 8 | 2.74 | .272 | 1.12 | 6.9 | 3.3 | 6.6 | 72.1 | 55 | 22 | 22 | 7 | 26 | 53 | 0 | 37 | 5 | 0 | 0 | 0 | 0 | 3.88 |