| SP | Murphy, T.Murphy, Tom-LAA † # + | Angels | R | 155.0 | 31 | 31 | 18 | 9 | 2.90 | .255 | 1.00 | 6.7 | 2.3 | 6.3 | 242.1 | 181 | 81 | 78 | 31 | 62 | 170 | 11 | 0 | 0 | 2 | 24 | 6 | 2 | 4.10 |
| SP | Downing, A.Downing, Al-NYY † + | Yankees | L | 143.0 | 31 | 31 | 18 | 5 | 3.53 | .277 | 1.12 | 7.0 | 3.1 | 8.0 | 229.1 | 177 | 90 | 90 | 30 | 80 | 203 | 7 | 0 | 0 | 3 | 18 | 6 | 2 | 4.06 |
| SP | McKenzie, T.McKenzie, Triston † | Guardians | R | 141.0 | 32 | 32 | 20 | 8 | 3.99 | .284 | 1.16 | 8.4 | 2.0 | 9.4 | 243.1 | 228 | 111 | 108 | 32 | 55 | 254 | 7 | 0 | 0 | 2 | 14 | 6 | 6 | 3.37 |
| SP | Ryan, N.Ryan, Nolan-LAA + | Angels | R | 137.0 | 30 | 30 | 15 | 9 | 3.37 | .272 | 1.10 | 6.0 | 3.9 | 10.0 | 238.0 | 159 | 94 | 89 | 28 | 102 | 264 | 12 | 0 | 0 | 3 | 21 | 6 | 8 | 3.67 |
| SP | Liriano, F.Liriano, Francisco-MIN † + | Twins | L | 134.0 | 31 | 31 | 17 | 5 | 3.73 | .261 | 1.04 | 7.6 | 1.7 | 10.3 | 222.0 | 188 | 92 | 92 | 33 | 43 | 255 | 6 | 0 | 0 | 1 | 17 | 4 | 8 | 3.27 |
| SP | Pilkington, K.Pilkington, Konnor | Guardians | L | 132.0 | 29 | 29 | 17 | 4 | 2.76 | .264 | 1.02 | 7.2 | 2.0 | 7.9 | 176.1 | 141 | 64 | 54 | 23 | 39 | 154 | 0 | 0 | 0 | 0 | 18 | 10 | 3 | 3.78 |
| CL | Betances, D.Betances, Dellin-NYY † + | Yankees | R | 128.0 | 54 | 0 | 2 | 4 | 2.79 | .221 | 0.83 | 4.6 | 3.0 | 10.8 | 51.2 | 26 | 16 | 16 | 7 | 17 | 61 | 0 | 46 | 6 | 0 | 0 | 1 | 0 | 3.45 |