| SP | Scherzer, M.Scherzer, Max † | Metro | R | 128.0 | 21 | 21 | 12 | 4 | 1.89 | .263 | 1.06 | 6.8 | 2.7 | 11.2 | 157.0 | 119 | 35 | 33 | 9 | 47 | 195 | 3 | 0 | 0 | 3 | 20 | 2 | 1 | 2.20 |
| SP | Kluber, C.Kluber, Corey † | Bees | R | 94.0 | 20 | 20 | 11 | 5 | 2.85 | .300 | 1.22 | 8.6 | 2.4 | 9.6 | 139.0 | 133 | 46 | 44 | 7 | 37 | 148 | 3 | 0 | 0 | 1 | 14 | 9 | 2 | 2.52 |
| SP | Buchholz, C.Buchholz, Clay † | Prospectors | R | 84.0 | 20 | 20 | 13 | 5 | 3.57 | .297 | 1.25 | 8.6 | 2.6 | 8.1 | 126.0 | 120 | 53 | 50 | 13 | 37 | 113 | 0 | 0 | 0 | 0 | 13 | 3 | 1 | 3.50 |
| CL | Leclerc, J.Leclerc, Jose † | Yankees | R | 82.5 | 43 | 0 | 5 | 3 | 3.42 | .275 | 1.12 | 6.1 | 4.0 | 10.3 | 50.0 | 34 | 19 | 19 | 4 | 22 | 57 | 0 | 21 | 1 | 0 | 0 | 1 | 4 | 3.14 |
| SP | Buehler, W.Buehler, Walker † | Nightmares | R | 76.0 | 21 | 21 | 10 | 6 | 3.20 | .287 | 1.17 | 8.0 | 2.5 | 10.6 | 132.1 | 118 | 49 | 47 | 11 | 37 | 155 | 0 | 0 | 0 | 0 | 14 | 5 | 3 | 2.69 |
| SP | Kershaw, C.Kershaw, Clayton | Suns | L | 75.0 | 20 | 20 | 9 | 4 | 3.21 | .272 | 1.08 | 7.8 | 2.0 | 8.7 | 134.2 | 116 | 52 | 48 | 15 | 30 | 129 | 1 | 0 | 0 | 1 | 15 | 5 | 7 | 3.31 |