| CL | Doolittle, S.Doolittle, Sean † | Aces and Eights | L | 129.5 | 72 | 0 | 2 | 6 | 2.90 | .249 | 0.98 | 6.0 | 2.9 | 7.7 | 68.1 | 45 | 22 | 22 | 6 | 22 | 58 | 0 | 47 | 5 | 0 | 0 | 1 | 0 | 3.46 |
| SP | Koufax, S.Koufax, Sandy † | Astros | L | 126.0 | 36 | 36 | 16 | 11 | 3.56 | .286 | 1.18 | 7.7 | 3.0 | 8.2 | 252.2 | 215 | 106 | 100 | 30 | 84 | 229 | 7 | 0 | 0 | 2 | 20 | 5 | 2 | 3.79 |
| CL | Jansen, K.Jansen, Kenley † # | REPUBLICANS | R | 123.0 | 92 | 0 | 9 | 5 | 4.97 | .320 | 1.38 | 9.4 | 3.2 | 9.6 | 99.2 | 103 | 63 | 55 | 14 | 35 | 106 | 0 | 34 | 5 | 0 | 0 | 3 | 3 | 3.85 |
| RP | Feliz, N.Feliz, Neftali † | Classics | R | 113.0 | 76 | 0 | 6 | 5 | 2.22 | .252 | 0.98 | 5.9 | 3.0 | 8.8 | 109.2 | 72 | 28 | 27 | 8 | 36 | 107 | 0 | 22 | 3 | 0 | 0 | 3 | 0 | 3.06 |
| CL | Wagner, B.Wagner, Billy † | Astros | L | 110.5 | 64 | 0 | 4 | 6 | 3.09 | .309 | 1.33 | 6.7 | 5.2 | 10.5 | 67.0 | 50 | 24 | 23 | 4 | 39 | 78 | 0 | 35 | 5 | 0 | 0 | 1 | 1 | 3.24 |