| CL | Kimbrel, C.Kimbrel, Craig † | Athletics | R | 131.5 | 68 | 0 | 8 | 5 | 2.96 | .295 | 1.23 | 7.0 | 4.1 | 9.4 | 82.0 | 64 | 28 | 27 | 10 | 37 | 86 | 0 | 31 | 1 | 0 | 0 | 2 | 3 | 3.91 |
| SP | Koufax, S.Koufax, Sandy # | Apocalypse | L | 113.0 | 32 | 32 | 12 | 11 | 3.54 | .275 | 1.10 | 7.1 | 2.8 | 8.3 | 252.0 | 199 | 108 | 99 | 30 | 79 | 231 | 12 | 0 | 0 | 3 | 21 | 9 | 2 | 3.76 |
| SP | Leonard, D.Leonard, Dutch | X-Giants | L | 112.0 | 32 | 32 | 17 | 8 | 3.74 | .290 | 1.22 | 8.1 | 2.9 | 5.4 | 202.1 | 182 | 86 | 84 | 14 | 64 | 121 | 3 | 0 | 0 | 2 | 20 | 2 | 0 | 3.68 |
| SP | Brown, M.Brown, Mordecai † | Tigers | R | 110.0 | 28 | 28 | 15 | 6 | 3.72 | .281 | 1.15 | 8.1 | 2.3 | 3.2 | 218.0 | 195 | 93 | 90 | 28 | 56 | 78 | 9 | 0 | 0 | 1 | 17 | 4 | 5 | 4.78 |
| SP | Johnson, W.Johnson, Walter † | HAWGS | R | 108.0 | 32 | 32 | 16 | 10 | 3.62 | .306 | 1.30 | 9.3 | 2.4 | 5.0 | 231.0 | 239 | 102 | 93 | 18 | 61 | 129 | 3 | 0 | 0 | 0 | 20 | 5 | 2 | 3.75 |