| SP | Skubal, T.Skubal, Tarik † | Sharks | L | 168.0 | 37 | 37 | 19 | 8 | 2.78 | .268 | 1.04 | 7.1 | 2.3 | 10.9 | 252.2 | 199 | 79 | 78 | 21 | 63 | 306 | 1 | 0 | 0 | 1 | 27 | 16 | 6 | 2.60 |
| CL | Miller, M.Miller, Mason † | Metro | R | 161.0 | 68 | 0 | 10 | 6 | 2.61 | .252 | 0.98 | 5.8 | 3.1 | 10.6 | 72.1 | 46 | 23 | 21 | 5 | 25 | 85 | 0 | 40 | 3 | 0 | 0 | 2 | 1 | 2.67 |
| RP | Clase, E.Clase, Emmanuel † | Suns | R | 114.5 | 90 | 0 | 20 | 5 | 3.97 | .283 | 1.16 | 8.3 | 2.2 | 8.1 | 133.2 | 123 | 60 | 59 | 19 | 32 | 119 | 0 | 1 | 1 | 0 | 0 | 3 | 4 | 3.86 |
| SP | Wheeler, Z.Wheeler, Zack † | .44 Waivers | R | 105.0 | 38 | 38 | 17 | 7 | 4.52 | .309 | 1.32 | 9.1 | 2.8 | 10.3 | 229.0 | 231 | 118 | 115 | 29 | 72 | 263 | 1 | 0 | 0 | 0 | 23 | 4 | 5 | 3.34 |
| SP | Burnes, C.Burnes, Corbin † # | Knights | R | 101.0 | 33 | 33 | 15 | 9 | 3.74 | .289 | 1.18 | 7.6 | 3.0 | 8.7 | 192.1 | 163 | 86 | 80 | 18 | 63 | 185 | 2 | 0 | 0 | 1 | 19 | 9 | 8 | 3.42 |
| SP | Hurter, B.Hurter, Brant † | Knights | L | 99.0 | 36 | 36 | 16 | 10 | 3.51 | .283 | 1.18 | 8.6 | 2.0 | 7.4 | 174.1 | 166 | 74 | 68 | 19 | 39 | 143 | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 3.47 |