| SP | Alexander, P.Alexander, Pete † $ | Gaels | R | 163.0 | 34 | 34 | 19 | 8 | 2.47 | .265 | 1.08 | 7.1 | 2.6 | 4.9 | 233.1 | 183 | 77 | 64 | 14 | 68 | 126 | 6 | 0 | 0 | 3 | 25 | 2 | 3 | 3.60 |
| SP | Verlander, J.Verlander, Justin # $$ | Night Hawks | R | 155.0 | 36 | 36 | 21 | 10 | 3.38 | .302 | 1.27 | 9.3 | 2.2 | 7.7 | 261.1 | 269 | 103 | 98 | 28 | 63 | 224 | 5 | 0 | 0 | 0 | 24 | 7 | 2 | 3.48 |
| CL | Chapman, A.Chapman, Aroldis † | Classics | L | 154.0 | 70 | 0 | 1 | 1 | 3.47 | .275 | 1.14 | 6.0 | 4.4 | 9.1 | 62.1 | 41 | 25 | 24 | 2 | 30 | 63 | 0 | 58 | 9 | 0 | 0 | 0 | 6 | 2.84 |
| SP | Mathewson, C.Mathewson, Christy | Classics | R | 151.0 | 35 | 35 | 22 | 5 | 3.67 | .289 | 1.19 | 8.6 | 2.1 | 4.6 | 250.1 | 239 | 106 | 102 | 27 | 58 | 129 | 3 | 0 | 0 | 2 | 18 | 8 | 3 | 4.16 |
| CL | Betances, D.Betances, Dellin † | Wawa’s | R | 143.5 | 70 | 0 | 5 | 4 | 2.56 | .304 | 1.29 | 7.3 | 4.4 | 9.0 | 70.1 | 57 | 24 | 20 | 4 | 34 | 70 | 0 | 43 | 4 | 0 | 0 | 1 | 6 | 3.24 |
| SP | Leonard, D.Leonard, Dutch | Gaels | L | 135.0 | 36 | 36 | 18 | 8 | 3.15 | .287 | 1.21 | 8.0 | 2.9 | 5.4 | 237.1 | 210 | 91 | 83 | 14 | 76 | 141 | 2 | 0 | 0 | 0 | 25 | 1 | 4 | 3.55 |
| SP | Koufax, S.Koufax, Sandy # | Spiders | L | 127.0 | 34 | 34 | 15 | 12 | 3.72 | .287 | 1.20 | 8.0 | 2.7 | 8.2 | 254.0 | 227 | 106 | 105 | 24 | 77 | 231 | 17 | 0 | 0 | 4 | 19 | 3 | 2 | 3.35 |