| SP | Arrieta, J.Arrieta, Jake † | Elephants | R | 104.0 | 21 | 21 | 12 | 6 | 2.44 | .280 | 1.13 | 6.6 | 3.6 | 9.4 | 147.1 | 108 | 43 | 40 | 13 | 58 | 154 | 2 | 0 | 0 | 1 | 16 | 6 | 3 | 3.36 |
| CL | Eckersley, D.Eckersley, Dennis † | Spartans | R | 99.0 | 41 | 0 | 5 | 2 | 2.11 | .234 | 0.89 | 7.3 | 0.9 | 9.6 | 42.2 | 34 | 10 | 10 | 6 | 4 | 45 | 0 | 26 | 3 | 0 | 0 | 1 | 0 | 3.07 |
| SP | Scherzer, M.Scherzer, Max † # | Demons | R | 96.0 | 22 | 22 | 10 | 6 | 2.61 | .268 | 1.09 | 7.4 | 2.4 | 10.4 | 158.1 | 130 | 52 | 46 | 13 | 43 | 182 | 2 | 0 | 0 | 0 | 16 | 1 | 0 | 2.60 |
| SP | Fernandez, J.Fernandez, Jose † | Warriors | R | 88.0 | 21 | 21 | 12 | 3 | 3.44 | .307 | 1.29 | 7.7 | 4.0 | 9.1 | 136.0 | 116 | 53 | 52 | 15 | 60 | 138 | 0 | 0 | 0 | 0 | 15 | 5 | 1 | 3.84 |
| CL | Jansen, K.Jansen, Kenley † | HURRICANES | R | 80.0 | 41 | 0 | 3 | 1 | 3.32 | .266 | 1.04 | 6.5 | 2.9 | 9.2 | 43.1 | 31 | 17 | 16 | 5 | 14 | 44 | 0 | 24 | 3 | 0 | 0 | 2 | 0 | 3.58 |
| SP | deGrom, J.deGrom, Jacob # $ | Eagles | R | 78.0 | 22 | 22 | 10 | 7 | 3.46 | .281 | 1.13 | 7.6 | 2.5 | 10.7 | 143.0 | 121 | 57 | 55 | 9 | 40 | 170 | 2 | 0 | 0 | 2 | 16 | 7 | 0 | 2.43 |
| CL | Kimbrel, C.Kimbrel, Craig † | Drifters | R | 77.5 | 39 | 0 | 3 | 4 | 2.58 | .272 | 1.04 | 5.9 | 3.6 | 11.4 | 38.1 | 25 | 11 | 11 | 6 | 15 | 48 | 0 | 23 | 1 | 0 | 0 | 3 | 1 | 3.95 |
| SP | Martinez, P.Martinez, Pedro † | Tigers | R | 76.0 | 22 | 22 | 9 | 7 | 3.12 | .266 | 1.07 | 7.5 | 2.1 | 9.0 | 155.2 | 129 | 55 | 54 | 16 | 37 | 155 | 1 | 0 | 0 | 0 | 17 | 3 | 3 | 3.12 |