| CL | Chapman, A.Chapman, Aroldis † $ | Classics | L | 164.5 | 66 | 0 | 1 | 0 | 1.69 | .292 | 1.22 | 5.5 | 5.5 | 8.2 | 64.0 | 39 | 16 | 12 | 1 | 39 | 58 | 0 | 55 | 5 | 0 | 0 | 1 | 3 | 3.27 |
| SP | Martinez, P.Martinez, Pedro † | Serpents | R | 159.0 | 33 | 33 | 18 | 11 | 2.96 | .271 | 1.11 | 7.9 | 2.1 | 8.4 | 261.1 | 228 | 88 | 86 | 21 | 61 | 245 | 10 | 0 | 0 | 2 | 25 | 2 | 2 | 2.89 |
| SP | Greinke, Z.Greinke, Zack † | Classics | R | 130.0 | 34 | 34 | 16 | 13 | 3.03 | .251 | 1.00 | 6.6 | 2.4 | 5.8 | 252.1 | 185 | 93 | 85 | 19 | 67 | 163 | 7 | 0 | 0 | 1 | 23 | 2 | 9 | 3.51 |
| SP | Reulbach, E.Reulbach, Ed # | Mustangs | R | 126.0 | 31 | 31 | 16 | 8 | 3.19 | .280 | 1.15 | 7.0 | 3.4 | 4.3 | 231.1 | 179 | 85 | 82 | 17 | 87 | 110 | 7 | 0 | 0 | 0 | 24 | 4 | 3 | 4.19 |
| SP | Koufax, S.Koufax, Sandy † $ | Cats | L | 125.0 | 34 | 34 | 16 | 12 | 3.53 | .280 | 1.16 | 7.5 | 2.9 | 9.0 | 250.0 | 208 | 104 | 98 | 22 | 81 | 250 | 8 | 0 | 0 | 1 | 23 | 2 | 5 | 3.14 |
| CL | Wagner, B.Wagner, Billy † $$ | Colt 45's | L | 122.5 | 94 | 0 | 2 | 9 | 2.35 | .257 | 1.01 | 6.4 | 2.7 | 9.4 | 103.1 | 73 | 31 | 27 | 8 | 31 | 108 | 0 | 39 | 6 | 0 | 0 | 3 | 2 | 2.90 |
| SP | Mathewson, C.Mathewson, Christy # | Plunder | R | 121.0 | 32 | 32 | 17 | 10 | 3.49 | .264 | 1.07 | 7.6 | 2.0 | 4.8 | 224.1 | 190 | 91 | 87 | 26 | 49 | 120 | 7 | 0 | 0 | 2 | 22 | 2 | 2 | 4.12 |