| SP | Johnson, R.Johnson, Randy † | Destroyers | L | 177.0 | 38 | 38 | 20 | 10 | 2.75 | .278 | 1.12 | 7.3 | 2.8 | 9.9 | 275.1 | 223 | 91 | 84 | 20 | 85 | 302 | 3 | 0 | 0 | 1 | 30 | 10 | 3 | 2.79 |
| SP | Halladay, R.Halladay, Roy † | Destroyers | R | 143.0 | 36 | 36 | 17 | 8 | 3.34 | .273 | 1.09 | 7.9 | 1.9 | 6.0 | 253.0 | 223 | 97 | 94 | 33 | 53 | 170 | 12 | 0 | 0 | 2 | 23 | 9 | 3 | 4.09 |
| CL | Rivera, M.Rivera, Mariano † | Destroyers | R | 140.5 | 92 | 0 | 10 | 6 | 3.49 | .267 | 1.05 | 7.5 | 1.9 | 8.8 | 111.0 | 93 | 45 | 43 | 17 | 24 | 109 | 0 | 33 | 7 | 0 | 0 | 4 | 2 | 3.78 |
| SP | Lincecum, T.Lincecum, Tim † | Pointers | R | 131.0 | 38 | 38 | 21 | 13 | 4.00 | .285 | 1.17 | 7.5 | 3.1 | 9.3 | 259.0 | 216 | 120 | 115 | 26 | 88 | 269 | 2 | 0 | 0 | 0 | 23 | 5 | 7 | 3.31 |
| SP | Zambrano, C.Zambrano, Carlos # | Destroyers | R | 109.0 | 34 | 34 | 17 | 8 | 4.03 | .300 | 1.24 | 7.6 | 3.5 | 7.9 | 212.0 | 179 | 101 | 95 | 34 | 83 | 187 | 3 | 0 | 0 | 0 | 20 | 10 | 4 | 4.64 |
| SP | Martinez, P.Martinez, Pedro | Danes | R | 108.0 | 36 | 36 | 16 | 12 | 4.11 | .301 | 1.28 | 9.1 | 2.4 | 9.6 | 256.1 | 260 | 121 | 117 | 33 | 67 | 273 | 4 | 0 | 0 | 1 | 20 | 4 | 0 | 3.38 |